Sally is using a technique called electroencephalography (EEG) to investigate how the brain activity of adults with Down’s syndrome changes with age. EEG records activity in the outer part of the brain, called the cortex, through small disks called electrodes. People with Down’s Syndrome age prematurely and are at very high risk of Alzheimer’s disease, so Sally plans to use this non-invasive technique to explore changes associated with premature aging and cognitive decline. The ultimate goal is to find early markers of Alzheimer’s disease so that therapies, when they are developed, can be administered at the best time. Thanks to your help Sally has recruited 40 people with Down’s Syndrome and 39 age- and gender-matched controls into her study. Sally is also interested in whether people’s brain activity can predict their future performance on memory games and puzzles. Sally is currently concentrating on this follow-up part of the study.