Publications by members of the OAP group are listed here.
Title | Authors | Reference |
---|---|---|
Introduction of a Management Toolkit for Lewy Body Dementia: A Pilot Cluster‐Randomized Trial. | O'Brien JT, McKeith IG, Thomas AJ, Bamford C, Vale L, Hill S, Allan L, Finch T, McNally R, Hayes L, Surendranathan A. | Movement Disorders. 2021 36(1):143-51. |
Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography. | Mak E, Nicastro N, Malpetti M, Savulich G, Surendranathan A, Holland N, Passamonti L, Jones PS, Carter SF, Su L, Hong YT, Fryer TD, Williams GB, Aigbirhio F, Rowe JB, O’Brien JT. | Neurobiology of Aging. 2021 101:172-180. |
Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study. | Low A, Su L, Stefaniak JD, Mak E, Dounavi ME, Muniz-Terrera G, Ritchie K, Ritchie CW, Markus HS, O’Brien JT. | Neurobiology of Aging. 2021 98:124-133. |
11 C-UCB-J synaptic PET and multimodal imaging in Dementia with Lewy bodies. | Nicastro N, Holland N, Savulich G, Carter SF, Mak E, Hong YT, Sephton SM, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT. | European J Hybrid Imaging. 2020 4(25). doi:10.1186/s41824-020-00093-9 |
Neuroinflammation and tau co‐localize in vivo in progressive supranuclear palsy. | Malpetti M, Passamonti L, Rittman T, Jones PS, Rodríguez PV, Bevan‐Jones WR, Hong YT, Fryer TD, Aigbirhio FI, O’Brien JT, Rowe JB. | Annals of Neurology. 2020 88(6):1194-1204. |
Trauma and depressive symptomatology in middle-aged persons at high risk of dementia : the PREVENT Dementia Study. | Ritchie K, Carrière I, Gregory S, Watermeyer T, Danso S, Li Su, Ritchie C, O’Brien. | Journal of Neurology, Neurosurgery and Psychiatry. 2020 92:16-21. doi:10.1136/jnnp-2020-323823 |
In vivo PET imaging of neuroinflammation in familial frontotemporal dementia. | Malpetti M, Rittman T, Jones PS, Cope TE, Passamonti L, Bevan-Jones WR, Patterson K, Fryer TD , Hong YT, Aigbirhio FI, O’Brien JT, Rowe JB. | Journal of Neurology, Neurosurgery & Psychiatry. 2020 92:319-322. |
In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease. | Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT. | Journal of Neurology, Neurosurgery, and Psychiatry. 2020 92:45-52. doi:10.1136/jnnp-2020-323894. |
The challenges of COVID-19 for people with Dementia with Lewy Bodies and family caregivers. | Killen A, Olsen K, McKeith IG, Thomas AJ, O'Brien JT, Donaghy P, Taylor JP. | Int J Geriatr Psychiatry. 2020 35(12):1431-1436. doi: 10.1002/gps.5393. |
Drug Repositioning and Repurposing for Alzheimer’s Disease. | Ballard C, Aarsland D, Cummings J, O'Brien J, Mills R, Molinuevo JL, Fladby T, Williams G, Doherty P, Corbett A, Sultana J. | Nature Reviews Neurology. 2020 16:661–673. |
Synaptic Loss in Primary Tauopathies Revealed by [11C ]UCB‐J Positron Emission Tomography. | Holland N, Jones PS, Savulich G, Wiggins JK, Hong YT, Fryer TD, Manavaki R, Sephton SM, Boros I, Malpetti M, Hezemans FH, Aigbirhio FI, Coles JP, O’Brien J, Rowe JB. | Movement Disorders. 2020 35(10):1834-1842. doi:10.1002/mds.28188 |
Epigenetic Regulation in the pathophysiology of Lewy Body Dementia. | Chouliaras L, Kumar GS, Thomas AJ, Lunnon K, Chinnery PF, O’Brien JT. | Progress in Neurobiology. 2020 192(12):101822. https://doi.org/10.1016/j.pneurobio.2020.101822 |
Volumetric alterations in the hippocampal subfields of subjects at increased risk of dementia. | Dounavi ME, Mak E, Wells K, Ritchie K, Ritchie CW, Su L, O' Brien JT. | Neurobiology of Aging. 2020 91:36-44. https://doi.org/10.1016/j.neurobiolaging.2020.03.006. |
Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia. | McKeever A, Paris AF, Cullen J, Hayes L, Ritchie CW, Ritchie K, Waldman AD, Wells K, Busza A, Carriere I, O’Brien JT. | Journal of Alzheimer's Disease. 2020 75(4):1211-1218. doi: 10.3233/JAD-200238. |
Regional hyperperfusion in cognitively normal APOE 4 allele carriers in mid-life: analysis of ASL pilot data from the PREVENT-Dementia cohort. | McKiernan E, Mak E, Dounavi ME, Wells K, Ritchie C, Williams G, Su L, O’Brien J. | Journal of Neurology, Neurosurgery, and Psychiatry. 2020 0:1–6. doi:10.1136/jnnp-2020-322924. |
Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management. | O'Brien J, Taylor JP, Ballard C, Barker RA, Bradley C, Burns A, Collerton D, Dave S, Dudley R, Francis P, Gibbons A. | Journal of Neurology, Neurosurgery & Psychiatry. 2020 1;91(5):512-9. http://dx.doi.org/10.1136/jnnp-2019-322702. |
The Clinical Diagnosis of Lewy Body Dementia. | Surendranathan A, Kane JPM, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O’Brien JT. | BJPsych Open. 2020 16;6(4):e61. doi: 10.1192/bjo.2020.44. |
Grey matter changes related to microglial activation in Alzheimer's disease. | Nicastro N, Malpetti M, Mak E, Williams GB, Bevan-Jones WR, Carter SF, Passamonti L, Fryer TD, Hong YT, Aigbirhio FI, Rowe JB, O'Brien JT. | Neurobiology of Aging. 2020 94:236-242. |
Microglial activation and tau burden predict cognitive decline in Alzheimer's Disease. | Malpetti M, Kievit RA, Passamonti L, Jones PS, Tsvetanov KA, Rittman T, Mak E, Nicastro N, Bevan-Jones WR, Su L, Hong YT, Fryer TD, Aigbirhio FI, O’Brien JT, Rowe JB. | Brain. 2020. 143(5):1588–1602. https://doi.org/10.1093/brain/awaa088 |
Reduced synaptic density in progressive supranuclear palsy and corticobasal syndrome, revealed by [11C] UCB-J PET. | Holland N, Jones PS, Savulich G, Wiggins JK, Hong YT, Fryer TD, Manavaki R, Milicevic-Sephton S, Boros I, Hezemans FH, Aigbirhio FI, Coles JP, O'Brien J, Rowe JB. | Movement Disorders. 2020 35(10):1834-42. doi: https://doi.org/10.1101/2020.01.24.20018697 |
Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage. | Low A, Mak E, Stefaniak JD, Malpetti M, Nicastro N, Savulich G, Chouliaras L, Markus HS, Rowe JB, O’Brien JT. | Frontiers in Neuroscience. 2020 14:238. doi: 10.3389/fnins.2020.00238 |
Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum. | Bevan-Jones WR, Cope TE, Jones PS, Kaalund SS, Passamonti L, Allinson K, Green O, Hong YT, Fryer TD, Arnold R, Coles JP, Aigbirhio FI, Larner AJ, Patterson K, O’Brien JT, Rowe JB. | Brain. 2020 143(3):1010–1026, |
Research criteria for the diagnosis of prodromal dementia with Lewy bodies. | McKeith I, Ferman TJ, Thomas AJ, Blanc F, Bradley BF, Fujishiro H, Kantarci K, Muscio C, O’Brien J, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P. | Neurology. 2020 94:1-13. doi:10.1212/WNL.0000000000009323 |
New evidence on the management of Lewy body dementia. | Taylor JP, McKeith IG, Burn DJ, Boeve BF, Weintraub D, Bamford C, Allan LM, Thomas AJ, O'Brien JT. | Lancet Neurol. 2020 19(2):157-169. doi: 10.1016/S1474-4422(19)30153-X |
F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy. | Nicastro N, Rodriguez PV, Malpetti M, Bevan-Jones WR, Simon Jones P, Passamonti L, Aigbirhio FI, O'Brien JT, Rowe JB. | J Neurol. 2020 267(2):341-349. doi: 10.1007/s00415-019-09566-9 |
Deep learning-based automated speech detection as a marker of social functioning in late-life depression. | Little B, Alshabrawy O, Stow D, Ferrier I, McNaney R, Jackson D, Ladha K, Ladha C, Ploetz T, Bacardit J, Olivier P, Gallagher P, O'Brien J. | Psychological Medicine. 2020 1-10. doi: https://doi.org/10.1017/S0033291719003994 |
Correlation of microglial activation with white matter changes in dementia with Lewy bodies. | Nicastro N, Mak E, Williams GB, Surendranathan A, Bevan-Jones WR, Passamonti L, Rodriguez PV, Su L, Arnold R, Fryer TD, Hong YT. | NeuroImage: Clinical. 2020 25:102200 https://doi.org/10.1016/j.nicl.2020.102200 |
Association between midlife dementia risk factors and longitudinal brain atrophy: the PREVENT-Dementia study. | O'Brien JT, Firbank MJ, Ritchie K, Wells K, Williams GB, Ritchie CW, Su L. | Journal of Neurology, Neurosurgery & Psychiatry. 2020 91:158-161. |
Minocycline in Alzheimer Disease Efficacy (MADE) Trialist Group. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial. | Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, McShane R, Burns A, Ritchie C, Reeves S, Lovestone S, Ballard C, Noble W, Nilforooshan R, Wilcock G, Gray R. | JAMA Neurol. 2020 Feb 1;77(2):164-174.doi:10.1001/jamaneurol.2019.3762. |
Asymmetrical atrophy of thalamic subnuclei in Alzheimer's disease and amyloid-positive mild cognitive impairment is associated with key clinical features. | Low A, Mak E, Malpetti M, Chouliaras L, Nicastro N, Su L, Holland N, Rittman T, Rodríguez PV, Passamonti L, Bevan-Jones WR, Jones PS, Rowe JB, O'Brien JT. | Alzheimers Dement (Amst). 2019 1;11:690-699. doi:10.1016/j.dadm.2019.08.001. |
Clinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies. | Moylett S, Price A, Cardinal RN, Aarsland D, Mueller C, Stewart R, O'Brien JT. | J Alzheimers Dis. 2019 67(3):995-1005. doi: 10.3233/JAD-180877. |
Beta amyloid deposition maps onto hippocampal and subiculum atrophy in dementia with Lewy bodies. | Mak E, Donaghy PC, McKiernan E, Firbank MJ, Lloyd J, Petrides GS, Thomas AJ, O’Brien JT. | Neurobiology of Aging. 2018 73: 74-81. |
In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease. | Mak E, Bethlehem RAI, Romero-Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan-Jones RW, Passamonti L, Vazquez Rodriguez P, Su L, Arnold R, Williams GB, Hong YT, Fryer TD, Aigbirhio FI, Rowe JB, O’Brien JT. | Alzheimer’s & Dementia. 2018 10: 678-687. |
Early microglial activation and peripheral inflammation in dementia with Lewy bodies. | Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, Vazquez Rodriguez P, Bevan-Jones WR, Brain SAE, Fryer TD, Aigbirhio FI, Rowe JB, O’Brien JT. | Brain. 2018 141: 3415-3427. |
Clinical prevalence of Lewy body dementia. | Kane JPM, Surendranathan A, Bentley A, Barker SAH, Taylor JP, Thomas AJ, Allan LM, McNally RJ, James PW, McKeith IG, Burn DJ, O'Brien JT. | Alzheimers Res Ther. 2018 Feb 15;10(1):19. doi: 10.1186/s13195-018-0350-6. |
Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies. | Donaghy PC, Taylor JP, O'Brien JT, Barnett N, Olsen K, Colloby SJ, Lloyd J, Petrides G, McKeith IG, Thomas AJ. | Psychol Med. 2018 Jan 24:1-7. doi: 10.1017/S0033291717003956. [Epub ahead of print] |
Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy. | Cope TE, Rittman T, Borchert RJ, Jones PS, Vatansever D, Allinson K, Passamonti L, Vazquez Rodriguez P, Bevan-Jones WR, O'Brien JT, Rowe JB. | Brain. 2018 Feb 1;141(2):550-567. doi: 10.1093/brain/awx347. |
Peripheral inflammation in prodromal Alzheimer's and Lewy body dementias. | King E, O'Brien JT, Donaghy P, Morris C, Barnett N, Olsen K, Martin-Ruiz C, Taylor JP, Thomas AJ. | J Neurol Neurosurg Psychiatry. 2017 Dec 16. pii: jnnp-2017-317134. doi: 10.1136/jnnp-2017-317134. [Epub ahead of print] |
Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis. | Schumacher J, Peraza LR, Firbank M, Thomas AJ, Kaiser M, Gallagher P, O'Brien JT, Blamire AM, Taylor JP. | Hum Brain Mapp. 2018 Mar;39(3):1118-1129. doi: 10.1002/hbm.23901. Epub 2017 Nov 29. |
Hippocampal Stratum Radiatum, Lacunosum, and Moleculare Sparing in Mild Cognitive Impairment. | Su L, Hayes L, Soteriades S, Williams G, Brain SAE, Firbank MJ, Longoni G, Arnold RJ, Rowe JB, O'Brien JT. | J Alzheimers Dis. 2018;61(1):415-424. doi: 10.3233/JAD-170344. |
Cerebral small vessel disease in middle age and genetic predisposition to late-onset Alzheimer's disease. | Stefaniak JD, Su L, Mak E, Sheikh-Bahaei N, Wells K, Ritchie K, Waldman A, Ritchie CW, O'Brien JT. | Alzheimers Dement. 2018 Feb;14(2):253-258. doi: 10.1016/j.jalz.2017.08.017. Epub 2017 Nov 21. |
Non-pharmacological interventions for Lewy body dementia: a systematic review. | Connors MH, Quinto L, McKeith I, Brodaty H, Allan L, Bamford C, Thomas A, Taylor JP, O'Brien JT. | Psychol Med. 2017 Nov 16:1-10. doi: 10.1017/S0033291717003257. [Epub ahead of print] |
Mortality in dementia with Lewy bodies compared with Alzheimer's dementia: a retrospective naturalistic cohort study. | Price A, Farooq R, Yuan JM, Menon VB, Cardinal RN, O'Brien JT. | BMJ Open. 2017 Nov 3;7(11):e017504. doi: 10.1136/bmjopen-2017-017504. |
Long reaction times are associated with delayed brain activity in lewy body dementia. | Firbank MJ, O'Brien JT, Taylor JP. | Hum Brain Mapp. 2018 Feb;39(2):633-643. doi: 10.1002/hbm.23866. Epub 2017 Nov 2. |
Does attentional dysfunction and thalamic atrophy predict decline in dementia with Lewy bodies? | Watson R, Colloby SJ, Blamire AM, Wesnes KA, Wood J, O'Brien JT. | Parkinsonism Relat Disord. 2017 Dec;45:69-74. doi: 10.1016/j.parkreldis.2017.10.006. Epub 2017 Oct 9. |
Teaching provision for old age psychiatry in medical schools in the UK and Ireland: a survey. | Bennett S, Ilderton P, O'Brien JT, Taylor JP, Teodorczuk A. | BJPsych Bull. 2017 Oct;41(5):287-293. doi: 10.1192/pb.bp.116.055210. |
Structural and electrostatic effects at the surfaces of size- and charge-selected aqueous nanodrops. | Cooper RJ, O'Brien JT, Chang TM, Williams ER. | Chem Sci. 2017 Jul 1;8(7):5201-5213. doi: 10.1039/c7sc00481h. Epub 2017 May 19. |
[(18)F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia. | Bevan-Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer TD, Arnold R, Allinson KSJ, Coles JP, Aigbirhio FI, Patterson K, O'Brien JT, Rowe JB. | J Neurol Neurosurg Psychiatry. 2017 Sep 14. pii: jnnp-2017-316402. doi: 10.1136/jnnp-2017-316402. [Epub ahead of print] |
Cognitive Training Using a Novel Memory Game on an iPad in Patients with Amnestic Mild Cognitive Impairment (aMCI). | Savulich G, Piercy T, Fox C, Suckling J, Rowe JB, O'Brien JT, Sahakian BJ. | Int J Neuropsychopharmacol. 2017 Aug 1;20(8):624-633. doi: 10.1093/ijnp/pyx040. |
Author response: Autopsy validation of (123)I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB. | Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z. | Neurology. 2017 Aug 15;89(7):751. doi: 10.1212/WNL.0000000000004254. No abstract available. |
Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: Systematic review and consensus recommendations. | Webster L, Groskreutz D, Grinbergs-Saull A, Howard R, O'Brien JT, Mountain G, Banerjee S, Woods B, Perneczky R, Lafortune L, Roberts C, McCleery J, Pickett J, Bunn F, Challis D, Charlesworth G, Featherstone K, Fox C, Goodman C, Jones R, Lamb S, Moniz-Cook E, et al. | PLoS One. 2017 Jun 29;12(6):e0179521. doi: 10.1371/journal.pone.0179521. eCollection 2017. Review. |
Development of a core outcome set for disease modification trials in mild to moderate dementia: a systematic review, patient and public consultation and consensus recommendations. | Webster L, Groskreutz D, Grinbergs-Saull A, Howard R, O'Brien JT, Mountain G, Banerjee S, Woods B, Perneczky R, Lafortune L, Roberts C, McCleery J, Pickett J, Bunn F, Challis D, Charlesworth G, Featherstone K, Fox C, Goodman C, Jones R, Lamb S, Moniz-Cook E, et al. | Health Technol Assess. 2017 May;21(26):1-192. doi: 10.3310/hta21260. |
Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. | McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, et al. | Neurology. 2017 Jul 4;89(1):88-100. doi: 10.1212/WNL.0000000000004058. Epub 2017 Jun 7. Review. |
Symptoms associated with Lewy body disease in mild cognitive impairment. | Donaghy PC, Barnett N, Olsen K, Taylor JP, McKeith IG, O'Brien JT, Thomas AJ. | Int J Geriatr Psychiatry. 2017 Nov;32(11):1163-1171. doi: 10.1002/gps.4742. Epub 2017 May 29. |
Using DTI to assess white matter microstructure in cerebral small vessel disease (SVD) in multicentre studies. | Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O'Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K, Werring DJ, Blamire AM, Ford GA, Barrick TR, Markus HS. | Clin Sci (Lond). 2017 Jun 7;131(12):1361-1373. doi: 10.1042/CS20170146. Print 2017 Jun 1. |
Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis. | Harper L, Bouwman F, Burton EJ, Barkhof F, Scheltens P, O'Brien JT, Fox NC, Ridgway GR, Schott JM. | J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):908-916. doi: 10.1136/jnnp-2016-314978. Epub 2017 May 4. |
Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease. | Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Mollenhauer B, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O'Brien JT. | Neurobiol Aging. 2017 Jul;55:78-90. doi: 10.1016/j.neurobiolaging.2017.03.012. Epub 2017 Mar 16. |
The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies. | Elder GJ, Mactier K, Colloby SJ, Watson R, Blamire AM, O'Brien JT, Taylor JP. | Int J Geriatr Psychiatry. 2017 Nov;32(11):1182-1189. doi: 10.1002/gps.4719. Epub 2017 Apr 20. |
The midlife cognitive profiles of adults at high risk of late-onset Alzheimer's disease: The PREVENT study. | Ritchie K, Carrière I, Su L, O'Brien JT, Lovestone S, Wells K, Ritchie CW. | Alzheimers Dement. 2017 Oct;13(10):1089-1097. doi: 10.1016/j.jalz.2017.02.008. Epub 2017 Mar 30. |
Functional neuroimaging findings in healthy middle-aged adults at risk of Alzheimer's disease. | Habib M, Mak E, Gabel S, Su L, Williams G, Waldman A, Wells K, Ritchie K, Ritchie C, O'Brien JT. | Ageing Res Rev. 2017 Jul;36:88-104. doi: 10.1016/j.arr.2017.03.004. Epub 2017 Mar 22. Review. |
Cerebral glucose metabolism and cognition in newly diagnosed Parkinson's disease: ICICLE-PD study. | Firbank MJ, Yarnall AJ, Lawson RA, Duncan GW, Khoo TK, Petrides GS, O'Brien JT, Barker RA, Maxwell RJ, Brooks DJ, Burn DJ. | J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):310-316. doi: 10.1136/jnnp-2016-313918. Epub 2016 Oct 6. |
In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings. | Hall B, Mak E, Cervenka S, Aigbirhio FI, Rowe JB, O'Brien JT. | Ageing Res Rev. 2017 Jul;36:50-63. doi: 10.1016/j.arr.2017.03.002. Epub 2017 Mar 15. Review. |
Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia. | Alghamdi A, Vallortigara J, Howlett DR, Broadstock M, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Attems J, Francis PT, Whitfield DR. | J Alzheimers Dis. 2017;57(2):373-386. doi: 10.3233/JAD-160946. |
7T MRI for neurodegenerative dementias in vivo: a systematic review of the literature. | McKiernan EF, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2017 Jul;88(7):564-574. doi: 10.1136/jnnp-2016-315022. Epub 2017 Mar 4. Review. |
18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy. | Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KS, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB. | Brain. 2017 Mar 1;140(3):781-791. doi: 10.1093/brain/aww340. |
Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology. | O'Brien JT, Holmes C, Jones M, Jones R, Livingston G, McKeith I, Mittler P, Passmore P, Ritchie C, Robinson L, Sampson EL, Taylor JP, Thomas A, Burns A. | J Psychopharmacol. 2017 Feb;31(2):147-168. doi: 10.1177/0269881116680924. Epub 2017 Jan 20. Review. |
[(18)F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation. | Bevan Jones WR, Cope TE, Passamonti L, Fryer TD, Hong YT, Aigbirhio F, Kril JJ, Forrest SL, Allinson K, Coles JP, Simon Jones P, Spillantini MG, Hodges JR, O'Brien JT, Rowe JB. | Ann Clin Transl Neurol. 2016 Oct 18;3(12):940-947. doi: 10.1002/acn3.366. eCollection 2016 Dec. |
Multi-modal MRI investigation of volumetric and microstructural changes in the hippocampus and its subfields in mild cognitive impairment, Alzheimer's disease, and dementia with Lewy bodies. | Mak E, Gabel S, Su L, Williams GB, Arnold R, Passamonti L, Vazquez Rodríguez P, Surendranathan A, Bevan-Jones WR, Rowe JB, O'Brien JT. | Int Psychogeriatr. 2017 Apr;29(4):545-555. doi: 10.1017/S1041610216002143. Epub 2017 Jan 16. |
Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment. | Peraza LR, Nesbitt D, Lawson RA, Duncan GW, Yarnall AJ, Khoo TK, Kaiser M, Firbank MJ, O'Brien JT, Barker RA, Brooks DJ, Burn DJ, Taylor JP. | Hum Brain Mapp. 2017 Mar;38(3):1702-1715. doi: 10.1002/hbm.23499. Epub 2017 Jan 13. |
Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses. | Bevan-Jones WR, Surendranathan A, Passamonti L, Vázquez Rodríguez P, Arnold R, Mak E, Su L, Coles JP, Fryer TD, Hong YT, Williams G, Aigbirhio F, Rowe JB, O'Brien JT. | BMJ Open. 2017 Jan 7;7(1):e013187. doi: 10.1136/bmjopen-2016-013187. |
Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB. | Thomas AJ, Attems J, Colloby SJ, O'Brien JT, McKeith I, Walker R, Lee L, Burn D, Lett DJ, Walker Z. | Neurology. 2017 Jan 17;88(3):276-283. doi: 10.1212/WNL.0000000000003512. Epub 2016 Dec 9. |
Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review. | Martínez-Cengotitabengoa M, Carrascón L, O'Brien JT, Díaz-Gutiérrez MJ, Bermúdez-Ampudia C, Sanada K, Arrasate M, González-Pinto A. | Int J Mol Sci. 2016 Dec 2;17(12). pii: E2022. Review. |
The impact and measurement of social dysfunction in late-life depression: an evaluation of current methods with a focus on wearable technology. | Hodgetts S, Gallagher P, Stow D, Ferrier IN, O'Brien JT. | Int J Geriatr Psychiatry. 2017 Mar;32(3):247-255. doi: 10.1002/gps.4632. Epub 2016 Dec 2. Review. |
A spatial covariance (123)I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease. | Colloby SJ, Field RH, Wyper DJ, O'Brien JT, Taylor JP. | Neurobiol Aging. 2016 Nov;47:83-90. doi: 10.1016/j.neurobiolaging.2016.07.017. Epub 2016 Jul 30. |
Neuroinflammatory and morphological changes in late-life depression: the NIMROD study. | Su L, Faluyi YO, Hong YT, Fryer TD, Mak E, Gabel S, Hayes L, Soteriades S, Williams GB, Arnold R, Passamonti L, Rodríguez PV, Surendranathan A, Bevan-Jones RW, Coles J, Aigbirhio F, Rowe JB, O'Brien JT. | Br J Psychiatry. 2016 Dec;209(6):525-526. Epub 2016 Oct 6. |
Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial). | Knapp M, King D, Romeo R, Adams J, Baldwin A, Ballard C, Banerjee S, Barber R, Bentham P, Brown RG, Burns A, Dening T, Findlay D, Holmes C, Johnson T, Jones R, Katona C, Lindesay J, Macharouthu A, McKeith I, McShane R, O'Brien JT, et al. | Int J Geriatr Psychiatry. 2017 Dec;32(12):1205-1216. doi: 10.1002/gps.4583. Epub 2016 Oct 13. |
The segregated connectome of late-life depression: a combined cortical thickness and structural covariance analysis. | Mak E, Colloby SJ, Thomas A, O'Brien JT. | Neurobiol Aging. 2016 Dec;48:212-221. doi: 10.1016/j.neurobiolaging.2016.08.013. Epub 2016 Aug 24. |
A study of wrist-worn activity measurement as a potential real-world biomarker for late-life depression. | O'Brien JT, Gallagher P, Stow D, Hammerla N, Ploetz T, Firbank M, Ladha C, Ladha K, Jackson D, McNaney R, Ferrier IN, Olivier P. | Psychol Med. 2017 Jan;47(1):93-102. doi: 10.1017/S0033291716002166. Epub 2016 Sep 26. |
Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies. | Su L, Blamire AM, Watson R, He J, Hayes L, O'Brien JT. | Transl Psychiatry. 2016 Aug 30;6(8):e877. doi: 10.1038/tp.2016.140. |
Focusing the Neuroscience and Societal Implications of Cognitive Enhancers. | Savulich G, Piercy T, Brühl AB, Fox C, Suckling J, Rowe JB, O'Brien JT, Sahakian BJ. | Clin Pharmacol Ther. 2017 Feb;101(2):170-172. doi: 10.1002/cpt.457. Epub 2016 Sep 23. |
Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease. | Blanc F, Colloby SJ, Cretin B, de Sousa PL, Demuynck C, O'Brien JT, Martin-Hunyadi C, McKeith I, Philippi N, Taylor JP. | Alzheimers Res Ther. 2016 Jul 20;8:31. doi: 10.1186/s13195-016-0198-6. |
Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations. | Khundakar AA, Hanson PS, Erskine D, Lax NZ, Roscamp J, Karyka E, Tsefou E, Singh P, Cockell SJ, Gribben A, Ramsay L, Blain PG, Mosimann UP, Lett DJ, Elstner M, Turnbull DM, Xiang CC, Brownstein MJ, O'Brien JT, Taylor JP, Attems J, Thomas AJ, et al. | Acta Neuropathol Commun. 2016 Jun 30;4(1):66. doi: 10.1186/s40478-016-0334-3. |
Cholinergic and perfusion brain networks in Parkinson disease dementia. | Colloby SJ, McKeith IG, Burn DJ, Wyper DJ, O'Brien JT, Taylor JP. | Neurology. 2016 Jul 12;87(2):178-85. doi: 10.1212/WNL.0000000000002839. Epub 2016 Jun 15. |
Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis. | Wise T, Radua J, Via E, Cardoner N, Abe O, Adams TM, Amico F, Cheng Y, Cole JH, de Azevedo Marques Périco C, Dickstein DP, Farrow TFD, Frodl T, Wagner G, Gotlib IH, Gruber O, Ham BJ, Job DE, Kempton MJ, Kim MJ, Koolschijn PCMP, Malhi GS, et al. | Mol Psychiatry. 2017 Oct;22(10):1455-1463. doi: 10.1038/mp.2016.72. Epub 2016 May 24. |
Structural grey matter changes in the substantia innominata in Alzheimer's disease and dementia with Lewy bodies: a DARTEL-VBM study. | Colloby SJ, Elder GJ, Rabee R, O'Brien JT, Taylor JP. | Int J Geriatr Psychiatry. 2017 Jun;32(6):615-623. doi: 10.1002/gps.4500. Epub 2016 May 19. |
Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease. | De Guio F, Jouvent E, Biessels GJ, Black SE, Brayne C, Chen C, Cordonnier C, De Leeuw FE, Dichgans M, Doubal F, Duering M, Dufouil C, Duzel E, Fazekas F, Hachinski V, Ikram MA, Linn J, Matthews PM, Mazoyer B, Mok V, Norrving B, O'Brien JT, et al. | J Cereb Blood Flow Metab. 2016 Aug;36(8):1319-37. doi: 10.1177/0271678X16647396. Epub 2016 May 11. Review. |
Multimodal EEG-MRI in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies. | Colloby SJ, Cromarty RA, Peraza LR, Johnsen K, Jóhannesson G, Bonanni L, Onofrj M, Barber R, O'Brien JT, Taylor JP. | J Psychiatr Res. 2016 Jul;78:48-55. doi: 10.1016/j.jpsychires.2016.03.010. Epub 2016 Mar 25. |
Regional functional synchronizations in dementia with Lewy bodies and Alzheimer's disease. | Peraza LR, Colloby SJ, Deboys L, O'Brien JT, Kaiser M, Taylor JP. | Int Psychogeriatr. 2016 Jul;28(7):1143-51. doi: 10.1017/S1041610216000429. Epub 2016 Mar 15. |
MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases. | Harper L, Fumagalli GG, Barkhof F, Scheltens P, O'Brien JT, Bouwman F, Burton EJ, Rohrer JD, Fox NC, Ridgway GR, Schott JM. | Brain. 2016 Apr;139(Pt 4):1211-25. doi: 10.1093/brain/aww005. Epub 2016 Mar 1. |
Computational meta-analysis of statistical parametric maps in major depression. | Arnone D, Job D, Selvaraj S, Abe O, Amico F, Cheng Y, Colloby SJ, O'Brien JT, Frodl T, Gotlib IH, Ham BJ, Kim MJ, Koolschijn PC, Périco CA, Salvadore G, Thomas AJ, Van Tol MJ, van der Wee NJ, Veltman DJ, Wagner G, McIntosh AM. | Hum Brain Mapp. 2016 Apr;37(4):1393-404. doi: 10.1002/hbm.23108. Epub 2016 Feb 8. Review. |
Exome sequencing in dementia with Lewy bodies. | Keogh MJ, Kurzawa-Akanbi M, Griffin H, Douroudis K, Ayers KL, Hussein RI, Hudson G, Pyle A, Cordell HJ, Attems J, McKeith IG, O'Brien JT, Burn DJ, Morris CM, Thomas AJ, Chinnery PF. | Transl Psychiatry. 2016 Feb 2;6:e728. doi: 10.1038/tp.2015.220. |
Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias. | Chen A, Oakley AE, Monteiro M, Tuomela K, Allan LM, Mukaetova-Ladinska EB, O'Brien JT, Kalaria RN. | Neurobiol Aging. 2016 Feb;38:56-67. doi: 10.1016/j.neurobiolaging.2015.10.021. Epub 2015 Oct 30. |
Longitudinal diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. | Firbank MJ, Watson R, Mak E, Aribisala B, Barber R, Colloby SJ, He J, Blamire AM, O'Brien JT. | Parkinsonism Relat Disord. 2016 Mar;24:76-80. doi: 10.1016/j.parkreldis.2016.01.003. Epub 2016 Jan 6. |
Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer's disease. | Firbank M, Kobeleva X, Cherry G, Killen A, Gallagher P, Burn DJ, Thomas AJ, O'Brien JT, Taylor JP. | Hum Brain Mapp. 2016 Mar;37(3):1254-70. doi: 10.1002/hbm.23100. Epub 2015 Dec 26. |
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia. | Chen A, Akinyemi RO, Hase Y, Firbank MJ, Ndung'u MN, Foster V, Craggs LJ, Washida K, Okamoto Y, Thomas AJ, Polvikoski TM, Allan LM, Oakley AE, O'Brien JT, Horsburgh K, Ihara M, Kalaria RN. | Brain. 2016 Jan;139(Pt 1):242-58. doi: 10.1093/brain/awv328. Epub 2015 Dec 14. |
Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia. | Vallortigara J, Whitfield D, Quelch W, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, O'Brien JT, Thomas A, Ballard CG, Aarsland D, Francis PT. | J Alzheimers Dis. 2016;50(1):101-10. doi: 10.3233/JAD-150707. |
A Winding Road: Alzheimer's Disease Increases Circuitous Functional Connectivity Pathways. | Suckling J, Simas T, Chattopadhyay S, Tait R, Su L, Williams G, Rowe JB, O'Brien JT. | Front Comput Neurosci. 2015 Nov 18;9:140. doi: 10.3389/fncom.2015.00140. eCollection 2015. |
Vascular dementia. | O'Brien JT, Thomas A. | Lancet. 2015 Oct 24;386(10004):1698-706. doi: 10.1016/S0140-6736(15)00463-8. Review. |
Subcortical volume changes in dementia with Lewy bodies and Alzheimer's disease. A comparison with healthy aging. | Watson R, Colloby SJ, Blamire AM, O'Brien JT. | Int Psychogeriatr. 2016 Apr;28(4):529-36. doi: 10.1017/S1041610215001805. Epub 2015 Nov 17. |
Cortical and Subcortical Changes in Alzheimer's Disease: A Longitudinal and Quantitative MRI Study. | Su L, Blamire AM, Watson R, He J, Aribisala B, O'Brien JT. | Curr Alzheimer Res. 2016;13(5):534-44. |
Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies. | Elder GJ, Colloby SJ, Lett DJ, O'Brien JT, Anderson KN, Burn DJ, McKeith IG, Taylor JP. | Int J Geriatr Psychiatry. 2016 Jul;31(7):765-70. doi: 10.1002/gps.4389. Epub 2015 Nov 11. |
Visual cortical excitability in dementia with Lewy bodies. | Taylor JP, Firbank M, O'Brien JT. | Br J Psychiatry. 2016 May;208(5):497-8. doi: 10.1192/bjp.bp.114.152736. Epub 2015 Nov 5. |
Neuroinflammation in Lewy body dementia. | Surendranathan A, Rowe JB, O'Brien JT. | Parkinsonism Relat Disord. 2015 Dec;21(12):1398-406. doi: 10.1016/j.parkreldis.2015.10.009. Epub 2015 Oct 9. Review. |
Management of late-life depression: a major leap forward. | Thomas A, O'Brien JT. | Lancet. 2015 Dec 12;386(10011):2374-5. doi: 10.1016/S0140-6736(15)00304-9. Epub 2015 Sep 27. No abstract available. |
Cortical tau load is associated with white matter hyperintensities. | McAleese KE, Firbank M, Dey M, Colloby SJ, Walker L, Johnson M, Beverley JR, Taylor JP, Thomas AJ, O'Brien JT, Attems J. | Acta Neuropathol Commun. 2015 Sep 30;3:60. doi: 10.1186/s40478-015-0240-0. |
CT-based attenuation and scatter correction compared with uniform attenuation correction in brain perfusion SPECT imaging for dementia. | Gillen R, Firbank MJ, Lloyd J, O'Brien JT. | Phys Med Biol. 2015 Sep 7;60(17):6775-87. doi: 10.1088/0031-9155/60/17/6775. Epub 2015 Aug 21. |
The relationship between hallucinations and FDG-PET in dementia with Lewy bodies. | Firbank MJ, Lloyd J, O'Brien JT. | Brain Imaging Behav. 2016 Sep;10(3):636-9. doi: 10.1007/s11682-015-9434-0. |
Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease? | Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Brooks DJ, Barker RA, Burn DJ, O'Brien JT. | Mov Disord. 2016 Jan;31(1):103-10. doi: 10.1002/mds.26312. Epub 2015 Jul 22. |
Neurophysiological biomarkers for Lewy body dementias. | Cromarty RA, Elder GJ, Graziadio S, Baker M, Bonanni L, Onofrj M, O'Brien JT, Taylor JP. | Clin Neurophysiol. 2016 Jan;127(1):349-359. doi: 10.1016/j.clinph.2015.06.020. Epub 2015 Jun 27. Review. |
Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study. | Mak E, Su L, Williams GB, Firbank MJ, Lawson RA, Yarnall AJ, Duncan GW, Owen AM, Khoo TK, Brooks DJ, Rowe JB, Barker RA, Burn DJ, O'Brien JT. | Brain. 2015 Oct;138(Pt 10):2974-86. doi: 10.1093/brain/awv211. Epub 2015 Jul 14. |
Amyloid imaging for dementia in clinical practice. | O'Brien JT, Herholz K. | BMC Med. 2015 Jul 13;13:163. doi: 10.1186/s12916-015-0404-6. |
Regional covariance of muscarinic acetylcholine receptors in Alzheimer's disease using (R, R) [(123)I]-QNB SPECT. | Colloby SJ, McKeith IG, Wyper DJ, O'Brien JT, Taylor JP. | J Neurol. 2015 Sep;262(9):2144-53. doi: 10.1007/s00415-015-7827-z. Epub 2015 Jun 30. |
Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis. | Stinton C, McKeith I, Taylor JP, Lafortune L, Mioshi E, Mak E, Cambridge V, Mason J, Thomas A, O'Brien JT. | Am J Psychiatry. 2015 Aug 1;172(8):731-42. doi: 10.1176/appi.ajp.2015.14121582. Epub 2015 Jun 18. Review. |
Cortical Thickness in Dementia with Lewy Bodies and Alzheimer's Disease: A Comparison of Prodromal and Dementia Stages. | Blanc F, Colloby SJ, Philippi N, de Pétigny X, Jung B, Demuynck C, Phillipps C, Anthony P, Thomas A, Bing F, Lamy J, Martin-Hunyadi C, O'Brien JT, Cretin B, McKeith I, Armspach JP, Taylor JP. | PLoS One. 2015 Jun 10;10(6):e0127396. doi: 10.1371/journal.pone.0127396. eCollection 2015. |
An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy. | Firbank MJ, Lloyd J, Williams D, Barber R, Colloby SJ, Barnett N, Olsen K, Davison C, Donaldson C, Herholz K, O'Brien JT. | Br J Psychiatry. 2016 May;208(5):491-6. doi: 10.1192/bjp.bp.114.160804. Epub 2015 Jun 4. |
Neuroimaging correlates of cognitive impairment and dementia in Parkinson's disease. | Mak E, Su L, Williams GB, O'Brien JT. | Parkinsonism Relat Disord. 2015 Aug;21(8):862-70. doi: 10.1016/j.parkreldis.2015.05.013. Epub 2015 May 19. Review. |
Changes to the lateral geniculate nucleus in Alzheimer's disease but not dementia with Lewy bodies. | Erskine D, Taylor JP, Firbank MJ, Patterson L, Onofrj M, O'Brien JT, McKeith IG, Attems J, Thomas AJ, Morris CM, Khundakar AA. | Neuropathol Appl Neurobiol. 2016 Jun;42(4):366-76. doi: 10.1111/nan.12249. Epub 2015 Jun 2. |
EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease. | Schmidt R, Hofer E, Bouwman FH, Buerger K, Cordonnier C, Fladby T, Galimberti D, Georges J, Heneka MT, Hort J, Laczó J, Molinuevo JL, O'Brien JT, Religa D, Scheltens P, Schott JM, Sorbi S. | Eur J Neurol. 2015 Jun;22(6):889-98. doi: 10.1111/ene.12707. Epub 2015 Mar 25. Review. |
Commentary on: Psychotic symptoms in frontotemporal dementia: a diagnostic dilemma? | O'brien JT. | Int Psychogeriatr. 2015 Apr;27(4):529-30. doi: 10.1017/S1041610214002920. No abstract available. |
Longitudinal assessment of global and regional atrophy rates in Alzheimer's disease and dementia with Lewy bodies. | Mak E, Su L, Williams GB, Watson R, Firbank M, Blamire AM, O'Brien JT. | Neuroimage Clin. 2015 Feb 7;7:456-62. doi: 10.1016/j.nicl.2015.01.017. eCollection 2015. |
Progressive cortical thinning and subcortical atrophy in dementia with Lewy bodies and Alzheimer's disease. | Mak E, Su L, Williams GB, Watson R, Firbank MJ, Blamire AM, O'Brien JT. | Neurobiol Aging. 2015 Apr;36(4):1743-1750. doi: 10.1016/j.neurobiolaging.2014.12.038. Epub 2015 Jan 8. |
Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) of live plant tissue with plume capture by continuous flow solvent probe. | O'Brien JT, Williams ER, Holman HY. | Anal Chem. 2015 Mar 3;87(5):2631-8. doi: 10.1021/ac503383p. Epub 2015 Feb 9. |
Neuropsychiatric outcomes after stroke--authors' reply. | Köhler S, Hackett ML, O'Brien JT, Mead GE. | Lancet Neurol. 2014 Dec;13(12):1168-9. doi: 10.1016/S1474-4422(14)70226-1. Epub 2014 Nov 10. No abstract available. |
18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias. | O'Brien JT, Firbank MJ, Davison C, Barnett N, Bamford C, Donaldson C, Olsen K, Herholz K, Williams D, Lloyd J. | J Nucl Med. 2014 Dec;55(12):1959-65. doi: 10.2967/jnumed.114.143347. Epub 2014 Nov 5. |
Vascular risk factors and Alzheimer's disease. | O'Brien JT, Markus HS. | BMC Med. 2014 Nov 11;12:218. doi: 10.1186/s12916-014-0218-y. |
Commentary on: Amnestic mild cognitive impairment and incident dementia and Alzheimer's disease in geriatric depression. | O'brien JT. | Int Psychogeriatr. 2014 Dec;26(12):2027-8. doi: 10.1017/S1041610214002087. No abstract available. |
Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study. | Frederiksen KS, Verdelho A, Madureira S, Bäzner H, O'Brien JT, Fazekas F, Scheltens P, Schmidt R, Wallin A, Wahlund LO, Erkinjunttii T, Poggesi A, Pantoni L, Inzitari D, Waldemar G; LADIS Study.. | Int J Geriatr Psychiatry. 2015 Jul;30(7):744-50. doi: 10.1002/gps.4220. Epub 2014 Nov 3. |
Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI. | Su L, Blamire AM, Watson R, He J, Aribisala B, O'Brien JT. | J Neurol. 2015 Jan;262(1):165-72. doi: 10.1007/s00415-014-7541-2. Epub 2014 Oct 30. |
Biomarkers in dementia: clinical utility and new directions. | Ahmed RM, Paterson RW, Warren JD, Zetterberg H, O'Brien JT, Fox NC, Halliday GM, Schott JM. | J Neurol Neurosurg Psychiatry. 2014 Dec;85(12):1426-34. doi: 10.1136/jnnp-2014-307662. Epub 2014 Sep 26. Review. |
Assessment of regional gray matter loss in dementia with Lewy bodies: a surface-based MRI analysis. | Watson R, Colloby SJ, Blamire AM, O'Brien JT. | Am J Geriatr Psychiatry. 2015 Jan;23(1):38-46. doi: 10.1016/j.jagp.2014.07.005. Epub 2014 Jul 23. |
Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment. | Whitfield DR, Vallortigara J, Alghamdi A, Howlett D, Hortobágyi T, Johnson M, Attems J, Newhouse S, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT. | Neurobiol Aging. 2014 Dec;35(12):2836-2844. doi: 10.1016/j.neurobiolaging.2014.06.015. Epub 2014 Jun 17. |
Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias. | Howlett DR, Whitfield D, Johnson M, Attems J, O'Brien JT, Aarsland D, Lai MK, Lee JH, Chen C, Ballard C, Hortobágyi T, Francis PT. | Brain Pathol. 2015 Jul;25(4):401-8. doi: 10.1111/bpa.12182. Epub 2014 Oct 30. |
Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study. | Nombela C, Rowe JB, Winder-Rhodes SE, Hampshire A, Owen AM, Breen DP, Duncan GW, Khoo TK, Yarnall AJ, Firbank MJ, Chinnery PF, Robbins TW, O'Brien JT, Brooks DJ, Burn DJ; ICICLE-PD study group., Barker RA. | Brain. 2014 Oct;137(Pt 10):2743-58. doi: 10.1093/brain/awu201. Epub 2014 Jul 30. |
Prodromal dementia with Lewy bodies. | Donaghy PC, O'Brien JT, Thomas AJ. | Psychol Med. 2015 Jan;45(2):259-68. doi: 10.1017/S0033291714000816. Epub 2014 Apr 3. Review. |
Patterns of cerebellar volume loss in dementia with Lewy bodies and Alzheimer׳s disease: A VBM-DARTEL study. | Colloby SJ, O'Brien JT, Taylor JP. | Psychiatry Res. 2014 Sep 30;223(3):187-91. doi: 10.1016/j.pscychresns.2014.06.006. Epub 2014 Jun 30. |
Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks. | Lowther ER, O'Brien JT, Firbank MJ, Blamire AM. | Psychiatry Res. 2014 Sep 30;223(3):192-201. doi: 10.1016/j.pscychresns.2014.06.004. Epub 2014 Jun 27. |
Neuroimaging characteristics of dementia with Lewy bodies. | Mak E, Su L, Williams GB, O'Brien JT. | Alzheimers Res Ther. 2014 Apr 9;6(2):18. doi: 10.1186/alzrt248. eCollection 2014. Review. |
Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. | O'Brien JT, Oertel WH, McKeith IG, Grosset DG, Walker Z, Tatsch K, Tolosa E, Sherwin PF, Grachev ID. | BMJ Open. 2014 Jul 3;4(7):e005122. doi: 10.1136/bmjopen-2014-005122. |
Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia. | Whitfield DR, Vallortigara J, Alghamdi A, Hortobágyi T, Ballard C, Thomas AJ, O'Brien JT, Aarsland D, Francis PT. | Am J Geriatr Psychiatry. 2015 Feb;23(2):141-8. doi: 10.1016/j.jagp.2014.05.001. Epub 2014 May 14. |
Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan). | Grosset DG, Tatsch K, Oertel WH, Tolosa E, Bajaj N, Kupsch A, O'Brien JT, Seibyl J, Walker Z, Sherwin P, Chen C, Grachev ID. | J Nucl Med. 2014 Aug;55(8):1281-7. doi: 10.2967/jnumed.114.138032. Epub 2014 Jun 19. |
Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-ioflupane injection (DaTscan) imaging. | Seibyl JP, Kupsch A, Booij J, Grosset DG, Costa DC, Hauser RA, Darcourt J, Bajaj N, Walker Z, Marek K, McKeith I, O'Brien JT, Tatsch K, Tolosa E, Dierckx RA, Grachev ID. | J Nucl Med. 2014 Aug;55(8):1288-96. doi: 10.2967/jnumed.114.140228. Epub 2014 Jun 12. |
Plasma and platelet clusterin ratio is altered in Alzheimer's disease patients with distinct neuropsychiatric symptoms: findings from a pilot study. | Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, Alves da Silva J, O'Brien JT, Kalaria RN. | Int J Geriatr Psychiatry. 2015 Apr;30(4):368-75. doi: 10.1002/gps.4145. Epub 2014 Jun 12. |
Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum? | Gore RL, Vardy ER, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):50-9. doi: 10.1136/jnnp-2013-306389. Epub 2014 May 23. Review. |
Neuropsychiatric outcomes of stroke. | Hackett ML, Köhler S, O'Brien JT, Mead GE. | Lancet Neurol. 2014 May;13(5):525-34. doi: 10.1016/S1474-4422(14)70016-X. Epub 2014 Mar 28. Review. |
The importance of longitudinal cohort studies in understanding risk and protective factors for dementia. | O'Brien JT. | Int Psychogeriatr. 2014 Apr;26(4):541-2. doi: 10.1017/S104161021400009X. No abstract available. |
White matter and cognitive decline in aging: a focus on processing speed and variability. | Nilsson J, Thomas AJ, O'Brien JT, Gallagher P. | J Int Neuropsychol Soc. 2014 Mar;20(3):262-7. doi: 10.1017/S1355617713001458. Epub 2014 Feb 17. Review. |
Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. | Yarnall AJ, Breen DP, Duncan GW, Khoo TK, Coleman SY, Firbank MJ, Nombela C, Winder-Rhodes S, Evans JR, Rowe JB, Mollenhauer B, Kruse N, Hudson G, Chinnery PF, O'Brien JT, Robbins TW, Wesnes K, Brooks DJ, Barker RA, Burn DJ; ICICLE-PD Study Group.. | Neurology. 2014 Jan 28;82(4):308-16. doi: 10.1212/WNL.0000000000000066. Epub 2013 Dec 20. |
Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer's disease. | O'Donovan J, Watson R, Colloby SJ, Blamire AM, O'Brien JT. | Int Psychogeriatr. 2014 Apr;26(4):627-35. doi: 10.1017/S1041610213002317. Epub 2013 Dec 16. |
Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors. | Allan LM, Rowan EN, Thomas AJ, Polvikoski TM, O'Brien JT, Kalaria RN. | Br J Psychiatry. 2013 Dec;203(6):453-60. doi: 10.1192/bjp.bp.113.128355. Epub 2013 Oct 24. |
Covariant perfusion patterns provide clues to the origin of cognitive fluctuations and attentional dysfunction in dementia with Lewy bodies. | Taylor JP, Colloby SJ, McKeith IG, O'Brien JT. | Int Psychogeriatr. 2013 Dec;25(12):1917-28. doi: 10.1017/S1041610213001488. Epub 2013 Oct 23. |
A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review. | Davison CM, O'Brien JT. | Int J Geriatr Psychiatry. 2014 Jun;29(6):551-61. doi: 10.1002/gps.4036. Epub 2013 Oct 9. Review. |
Health-related quality of life in early Parkinson's disease: the impact of nonmotor symptoms. | Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, Barker RA, Burn DJ. | Mov Disord. 2014 Feb;29(2):195-202. doi: 10.1002/mds.25664. Epub 2013 Oct 7. |
Clinical significance of white matter changes. | O'Brien JT. | Am J Geriatr Psychiatry. 2014 Feb;22(2):133-7. doi: 10.1016/j.jagp.2013.07.006. Epub 2013 Sep 13. Review. |
The incidence of Parkinson's disease in the North-East of England. | Duncan GW, Khoo TK, Coleman SY, Brayne C, Yarnall AJ, O'Brien JT, Barker RA, Burn DJ. | Age Ageing. 2014 Mar;43(2):257-63. doi: 10.1093/ageing/aft091. Epub 2013 Jul 23. |
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. | Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, et al. | Lancet Neurol. 2013 Aug;12(8):822-38. doi: 10.1016/S1474-4422(13)70124-8. |
Subcortical connectivity in dementia with Lewy bodies and Alzheimer's disease. | Kenny ER, O'Brien JT, Firbank MJ, Blamire AM. | Br J Psychiatry. 2013 Sep;203(3):209-14. doi: 10.1192/bjp.bp.112.108464. Epub 2013 Jul 11. |
Amyloid PET Imaging in Lewy body disorders. | Donaghy P, Thomas AJ, O'Brien JT. | Am J Geriatr Psychiatry. 2015 Jan;23(1):23-37. doi: 10.1016/j.jagp.2013.03.001. Epub 2013 Jul 3. Review. |
Distinct cognitive phenotypes in Alzheimer's disease in older people. | Vardy ER, Ford AH, Gallagher P, Watson R, McKeith IG, Blamire A, O'Brien JT. | Int Psychogeriatr. 2013 Oct;25(10):1659-66. doi: 10.1017/S1041610213000914. Epub 2013 Jul 5. |
Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study. | Verdelho A, Madureira S, Moleiro C, Ferro JM, O'Brien JT, Poggesi A, Pantoni L, Fazekas F, Scheltens P, Waldemar G, Wallin A, Erkinjuntti T, Inzitari D; LADIS Study.. | J Neurol Neurosurg Psychiatry. 2013 Nov;84(11):1250-4. doi: 10.1136/jnnp-2012-304191. Epub 2013 May 28. |
Testing visual perception in dementia with Lewy bodies and Alzheimer disease. | Wood JS, Firbank MJ, Mosimann UP, Watson R, Barber R, Blamire AM, O'Brien JT. | Am J Geriatr Psychiatry. 2013 Jun;21(6):501-8. doi: 10.1016/j.jagp.2012.11.015. Epub 2013 Jan 11. |
Intensive blood pressure lowering increases cerebral blood flow in older subjects with hypertension. | Tryambake D, He J, Firbank MJ, O'Brien JT, Blamire AM, Ford GA. | Hypertension. 2013 Jun;61(6):1309-15. doi: 10.1161/HYPERTENSIONAHA.112.200972. Epub 2013 Mar 25. |
The prevalence and incidence of dementia with Lewy bodies: a systematic review of population and clinical studies. | Vann Jones SA, O'Brien JT. | Psychol Med. 2014 Mar;44(4):673-83. doi: 10.1017/S0033291713000494. Epub 2013 Mar 25. Review. Erratum in: Psychol Med. 2014 Mar;44(4):684. |
Patient involvement in research: an audit of study feedback to participants. | Barnett NA, O'Brien JT. | Int Psychogeriatr. 2013 Aug;25(8):1387-8. doi: 10.1017/S1041610213000227. Epub 2013 Mar 7. No abstract available. |
Rapid eye movement sleep behavior disorder in Parkinson's disease: magnetic resonance imaging study. | Ford AH, Duncan GW, Firbank MJ, Yarnall AJ, Khoo TK, Burn DJ, O'Brien JT. | Mov Disord. 2013 Jun;28(6):832-6. doi: 10.1002/mds.25367. Epub 2013 Feb 28. |
Magnetic resonance imaging: a biomarker for cognitive impairment in Parkinson's disease? | Duncan GW, Firbank MJ, O'Brien JT, Burn DJ. | Mov Disord. 2013 Apr;28(4):425-38. doi: 10.1002/mds.25352. Epub 2013 Feb 28. Review. |
Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis. | Colloby SJ, Taylor JP, Davison CM, Lloyd JJ, Firbank MJ, McKeith IG, O'Brien JT. | J Cereb Blood Flow Metab. 2013 Apr;33(4):612-8. doi: 10.1038/jcbfm.2013.2. Epub 2013 Jan 30. |
The spectrum of nonmotor symptoms in early Parkinson disease. | Khoo TK, Yarnall AJ, Duncan GW, Coleman S, O'Brien JT, Brooks DJ, Barker RA, Burn DJ. | Neurology. 2013 Jan 15;80(3):276-81. doi: 10.1212/WNL.0b013e31827deb74. |
Resting-state functional connectivity in late-life depression: higher global connectivity and more long distance connections. | Bohr IJ, Kenny E, Blamire A, O'Brien JT, Thomas AJ, Richardson J, Kaiser M. | Front Psychiatry. 2013 Jan 9;3:116. doi: 10.3389/fpsyt.2012.00116. eCollection 2012. |
White matter hyperintensities in mild lewy body dementia. | Oppedal K, Aarsland D, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK. | Dement Geriatr Cogn Dis Extra. 2012 Jan;2(1):481-95. doi: 10.1159/000343480. Epub 2012 Nov 9. |
Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study. | Poggesi A, Gouw A, van der Flier W, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien JT, Visser MC, Wahlund LO, Waldemar G, Wallin A, Scheltens P, Inzitari D, Pantoni L. | J Neurol. 2013 Apr;260(4):1014-21. doi: 10.1007/s00415-012-6748-3. Epub 2012 Nov 20. |
Commentary. | O'Brien JT. | Int Psychogeriatr. 2013 Feb;25(2):181-4. doi: 10.1017/S1041610212002116. Epub 2012 Nov 13. No abstract available. |
Introduction. | O'Brien JT. | Int Psychogeriatr. 2013 Feb;25(2):174-5. doi: 10.1017/S1041610212001652. Epub 2012 Nov 12. No abstract available. |
Magnetic resonance imaging of fixed post mortem brains reliably reflects subcortical vascular pathology of frontal, parietal and occipital white matter. | McAleese KE, Firbank M, Hunter D, Sun L, Hall R, Neal JW, Mann DM, Esiri M, Jellinger KA, O'Brien JT, Attems J. | Neuropathol Appl Neurobiol. 2013 Aug;39(5):485-97. doi: 10.1111/j.1365-2990.2012.01310.x. |
The influence of two common dementia types on visual symptoms. | Jefferis JM, Clarke MP, Mosimann UP, O'Brien JT, Taylor JP. | Acta Ophthalmol. 2013 Mar;91(2):e159-60. doi: 10.1111/j.1755-3768.2012.02544.x. Epub 2012 Oct 1. No abstract available. |
Neuropathological correlates of dopaminergic imaging in Alzheimer's disease and Lewy body dementias. | Colloby SJ, McParland S, O'Brien JT, Attems J. | Brain. 2012 Sep;135(Pt 9):2798-808. doi: 10.1093/brain/aws211. |
Multispectral MRI segmentation of age related white matter changes using a cascade of support vector machines. | Damangir S, Manzouri A, Oppedal K, Carlsson S, Firbank MJ, Sonnesyn H, Tysnes OB, O'Brien JT, Beyer MK, Westman E, Aarsland D, Wahlund LO, Spulber G. | J Neurol Sci. 2012 Nov 15;322(1-2):211-6. doi: 10.1016/j.jns.2012.07.064. Epub 2012 Aug 24. |
Characterizing dementia with Lewy bodies by means of diffusion tensor imaging. | Watson R, Blamire AM, Colloby SJ, Wood JS, Barber R, He J, O'Brien JT. | Neurology. 2012 Aug 28;79(9):906-14. doi: 10.1212/WNL.0b013e318266fc51. Epub 2012 Aug 15. |
Longitudinal testing of visual perception in dementia with Lewy bodies and Alzheimer's disease. | Wood JS, Watson R, Firbank MJ, Mosimann UP, Barber R, Blamire AM, O'Brien JT. | Int J Geriatr Psychiatry. 2013 Jun;28(6):567-72. doi: 10.1002/gps.3860. Epub 2012 Jul 22. |
Increase in platelet immunoglobulin in Alzheimer's disease is normalised following cholinesterase inhibitor treatment: preliminary results. | Mukaetova-Ladinska EB, Abdel-All Z, Andrade J, McNally RJ, James PW, Kalaria RN, O'Brien JT. | J Alzheimers Dis. 2012;32(2):431-6. doi: 10.3233/JAD-2012-120481. |
Does posterior cortical atrophy on MRI discriminate between Alzheimer's disease, dementia with Lewy bodies, and normal aging? | O'Donovan J, Watson R, Colloby SJ, Firbank MJ, Burton EJ, Barber R, Blamire AM, O'Brien JT. | Int Psychogeriatr. 2013 Jan;25(1):111-9. doi: 10.1017/S1041610212001214. Epub 2012 Jul 19. |
Water-induced folding of 1,7-diammoniumheptane. | Demireva M, O'Brien JT, Williams ER. | J Am Chem Soc. 2012 Jul 11;134(27):11216-24. doi: 10.1021/ja303313p. Epub 2012 Jun 29. |
Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study. | Firbank MJ, Teodorczuk A, van der Flier WM, Gouw AA, Wallin A, Erkinjuntti T, Inzitari D, Wahlund LO, Pantoni L, Poggesi A, Pracucci G, Langhorne P, O'Brien JT; LADIS group.. | Br J Psychiatry. 2012 Jul;201(1):40-5. doi: 10.1192/bjp.bp.111.098897. Epub 2012 May 24. |
Effects of ions on hydrogen-bonding water networks in large aqueous nanodrops. | O'Brien JT, Williams ER. | J Am Chem Soc. 2012 Jun 20;134(24):10228-36. doi: 10.1021/ja303191r. Epub 2012 Jun 5. |
Relationship between cognition, magnetic resonance white matter hyperintensities, and cardiovascular autonomic changes in late-life depression. | Vasudev A, Saxby BK, OʼBrien JT, Colloby SJ, Firbank MJ, Brooker H, Wesnes K, Thomas AJ. | Am J Geriatr Psychiatry. 2012 Aug;20(8):691-9. doi: 10.1097/JGP.0b013e31824c0435. |
Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study. | Taylor JP, Firbank MJ, He J, Barnett N, Pearce S, Livingstone A, Vuong Q, McKeith IG, O'Brien JT. | Br J Psychiatry. 2012 Jun;200(6):491-8. doi: 10.1192/bjp.bp.111.099432. Epub 2012 Apr 12. |
Quantitative neurodegenerative pathology does not explain the degree of hippocampal atrophy on MRI in degenerative dementia. | Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. | Int J Geriatr Psychiatry. 2012 Dec;27(12):1267-74. doi: 10.1002/gps.3774. Epub 2012 Mar 2. |
Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study. | Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten EC, Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H, Wahlund LO, O'Brien JT, Basile AM, Pantoni L, Inzitari D, Waldemar G. | Dement Geriatr Cogn Disord. 2011;32(4):279-86. doi: 10.1159/000334949. Epub 2012 Jan 19. |
Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study. | Mukaetova-Ladinska EB, Abdel-All Z, Dodds S, Andrade J, Alves da Silva J, Kalaria RN, O'Brien JT. | Age Ageing. 2012 May;41(3):408-12. doi: 10.1093/ageing/afr171. Epub 2012 Jan 17. |
Hippocampal neuronal atrophy and cognitive function in delayed poststroke and aging-related dementias. | Gemmell E, Bosomworth H, Allan L, Hall R, Khundakar A, Oakley AE, Deramecourt V, Polvikoski TM, O'Brien JT, Kalaria RN. | Stroke. 2012 Mar;43(3):808-14. doi: 10.1161/STROKEAHA.111.636498. Epub 2011 Dec 29. |
Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study. | Colloby SJ, Firbank MJ, He J, Thomas AJ, Vasudev A, Parry SW, O'Brien JT. | Br J Psychiatry. 2012 Feb;200(2):150-5. doi: 10.1192/bjp.bp.111.092387. Epub 2011 Dec 22. |
Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease. | Kenny ER, Blamire AM, Firbank MJ, O'Brien JT. | Brain. 2012 Feb;135(Pt 2):569-81. doi: 10.1093/brain/awr327. Epub 2011 Dec 20. |
Long term incidence of dementia, predictors of mortality and pathological diagnosis in older stroke survivors. | Allan LM, Rowan EN, Firbank MJ, Thomas AJ, Parry SW, Polvikoski TM, O'Brien JT, Kalaria RN. | Brain. 2011 Dec;134(Pt 12):3716-27. doi: 10.1093/brain/awr273. |
Post-stroke dementia: the contribution of thalamus and basal ganglia changes. | Lopes MA, Firbank MJ, Widdrington M, Blamire AM, Kalaria RN, O'Brien JT. | Int Psychogeriatr. 2012 Apr;24(4):568-76. doi: 10.1017/S1041610211002195. Epub 2011 Dec 12. |
Patterns of gray matter atrophy in dementia with Lewy bodies: a voxel-based morphometry study. | Watson R, O'Brien JT, Barber R, Blamire AM. | Int Psychogeriatr. 2012 Apr;24(4):532-40. doi: 10.1017/S1041610211002171. Epub 2011 Nov 30. |
Neuroimaging predictors of death and dementia in a cohort of older stroke survivors. | Firbank MJ, Allan LM, Burton EJ, Barber R, O'Brien JT, Kalaria RN. | J Neurol Neurosurg Psychiatry. 2012 Mar;83(3):263-7. doi: 10.1136/jnnp-2011-300873. Epub 2011 Nov 23. |
Coordination numbers of hydrated divalent transition metal ions investigated with IRPD spectroscopy. | O'Brien JT, Williams ER. | J Phys Chem A. 2011 Dec 29;115(51):14612-9. doi: 10.1021/jp210878s. Epub 2011 Dec 1. |
Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study. | Taylor JP, Firbank M, Barnett N, Pearce S, Livingstone A, Mosimann U, Eyre J, McKeith IG, O'Brien JT. | Br J Psychiatry. 2011 Dec;199(6):492-500. doi: 10.1192/bjp.bp.110.090373. Epub 2011 Oct 20. |
Diffusion tensor imaging in Alzheimer's disease and dementia with Lewy bodies. | Firbank MJ, Blamire AM, Teodorczuk A, Teper E, Mitra D, O'Brien JT. | Psychiatry Res. 2011 Nov 30;194(2):176-83. doi: 10.1016/j.pscychresns.2011.08.002. Epub 2011 Sep 29. |
PET imaging of brain amyloid in dementia: a review. | Quigley H, Colloby SJ, O'Brien JT. | Int J Geriatr Psychiatry. 2011 Oct;26(10):991-9. doi: 10.1002/gps.2640. Epub 2010 Dec 28. Review. |
Validation of automated white matter hyperintensity segmentation. | Smart SD, Firbank MJ, O'Brien JT. | J Aging Res. 2011;2011:391783. doi: 10.4061/2011/391783. Epub 2011 Sep 6. |
Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression. | Colloby SJ, Vasudev A, O'Brien JT, Firbank MJ, Parry SW, Thomas AJ. | Br J Psychiatry. 2011 Nov;199(5):404-10. doi: 10.1192/bjp.bp.110.090423. Epub 2011 Sep 8. |
White matter changes in late-life depression: a diffusion tensor imaging study. | Colloby SJ, Firbank MJ, Thomas AJ, Vasudev A, Parry SW, O'Brien JT. | J Affect Disord. 2011 Dec;135(1-3):216-20. doi: 10.1016/j.jad.2011.07.025. Epub 2011 Aug 20. |
Revised NIA-AA criteria for the diagnosis of Alzheimer's disease: a step forward but not yet ready for widespread clinical use. | Frisoni GB, Winblad B, O'Brien JT. | Int Psychogeriatr. 2011 Oct;23(8):1191-6. doi: 10.1017/S1041610211001220. Epub 2011 Aug 4. No abstract available. Erratum in: Int Psychogeriatr. 2012 Apr;24(4):682. |
Pain and distress in advanced dementia: choosing the right tools for the job. | Jordan A, Regnard C, O'Brien JT, Hughes JC. | Palliat Med. 2012 Oct;26(7):873-8. Epub 2011 Jul 7. |
Biomarkers in dementia with Lewy bodies: a review. | Sinha N, Firbank M, O'Brien JT. | Int J Geriatr Psychiatry. 2012 May;27(5):443-53. doi: 10.1002/gps.2749. Epub 2011 Jul 1. Review. |
Revised criteria for Alzheimer's disease: what are the lessons for clinicians? | Frisoni GB, Hampel H, O'Brien JT, Ritchie K, Winblad B. | Lancet Neurol. 2011 Jul;10(7):598-601. doi: 10.1016/S1474-4422(11)70126-0. No abstract available. |
Elevated plasma homocysteine is associated with increased brain atrophy rates in older subjects with mild hypertension. | Narayan SK, Firbank MJ, Saxby BK, Stansby G, Hansrani M, O'Brien JT, Ford GA. | Dement Geriatr Cogn Disord. 2011;31(5):341-8. doi: 10.1159/000328118. Epub 2011 May 18. |
Plasma homocysteine and cognitive decline in older hypertensive subjects. | Narayan SK, Saxby BK, Firbank MJ, O'Brien JT, Harrington F, McKeith IG, Hansrani M, Stansby G, Ford GA. | Int Psychogeriatr. 2011 Dec;23(10):1607-15. doi: 10.1017/S1041610211000779. Epub 2011 May 6. |
Cortical thickness and VBM-DARTEL in late-life depression. | Colloby SJ, Firbank MJ, Vasudev A, Parry SW, Thomas AJ, O'Brien JT. | J Affect Disord. 2011 Sep;133(1-2):158-64. doi: 10.1016/j.jad.2011.04.010. Epub 2011 May 8. |
Cerebral blood flow by arterial spin labeling in poststroke dementia. | Firbank MJ, He J, Blamire AM, Singh B, Danson P, Kalaria RN, O'Brien JT. | Neurology. 2011 Apr 26;76(17):1478-84. doi: 10.1212/WNL.0b013e318217e76a. |
Genetic associations of autopsy-confirmed vascular dementia subtypes. | Jones EL, Kalaria RN, Sharp SI, O'Brien JT, Francis PT, Ballard CG. | Dement Geriatr Cogn Disord. 2011;31(4):247-53. doi: 10.1159/000327171. Epub 2011 Apr 7. |
Development of a novel FMRI compatible visual perception prototype battery to test older people with and without dementia. | Wood JS, Firbank MJ, Mosimann UP, Taylor JP, O'Brien JT. | J Geriatr Psychiatry Neurol. 2011 Jun;24(2):73-83. doi: 10.1177/0891988711402348. Epub 2011 Apr 6. |
Structural and electric field effects of ions in aqueous nanodrops. | Prell JS, O'Brien JT, Williams ER. | J Am Chem Soc. 2011 Apr 6;133(13):4810-8. doi: 10.1021/ja108341t. Epub 2011 Mar 15. |
Neuropathological correlates of volumetric MRI in autopsy-confirmed Lewy body dementia. | Burton EJ, Mukaetova-Ladinska EB, Perry RH, Jaros E, Barber R, O'Brien JT. | Neurobiol Aging. 2012 Jul;33(7):1228-36. doi: 10.1016/j.neurobiolaging.2010.12.015. Epub 2011 Feb 24. |
A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression. | Vasudev A, O'Brien JT, Tan MP, Parry SW, Thomas AJ. | J Affect Disord. 2011 Jun;131(1-3):374-8. doi: 10.1016/j.jad.2010.11.001. Epub 2010 Nov 30. |
Clinical practice with anti-dementia drugs: a revised (second) consensus statement from the British Association for Psychopharmacology. | O'Brien JT, Burns A; BAP Dementia Consensus Group.. | J Psychopharmacol. 2011 Aug;25(8):997-1019. doi: 10.1177/0269881110387547. Epub 2010 Nov 18. |
Zn2+ has a primary hydration sphere of five: IR action spectroscopy and theoretical studies of hydrated Zn2+ complexes in the gas phase. | Cooper TE, O'Brien JT, Williams ER, Armentrout PB. | J Phys Chem A. 2010 Dec 9;114(48):12646-55. doi: 10.1021/jp1078345. Epub 2010 Nov 15. |
EFNS guidelines for the diagnosis and management of Alzheimer's disease. | Hort J, O'Brien JT, Gainotti G, Pirttila T, Popescu BO, Rektorova I, Sorbi S, Scheltens P; EFNS Scientist Panel on Dementia.. | Eur J Neurol. 2010 Oct;17(10):1236-48. doi: 10.1111/j.1468-1331.2010.03040.x. |
NOS3 gene rs1799983 polymorphism and incident dementia in elderly stroke survivors. | Morris CM, Ballard CG, Allan L, Rowan E, Stephens S, Firbank M, Ford GA, Kenny RA, O'Brien JT, Kalaria RN. | Neurobiol Aging. 2011 Mar;32(3):554.e1-6. doi: 10.1016/j.neurobiolaging.2010.06.012. Epub 2010 Aug 5. |
The utility of PAINAD in assessing pain in a UK population with severe dementia. | Jordan A, Hughes J, Pakresi M, Hepburn S, O'Brien JT. | Int J Geriatr Psychiatry. 2011 Feb;26(2):118-26. doi: 10.1002/gps.2489. |
Electrophysiological changes in late life depression and their relation to structural brain changes. | Köhler S, Ashton CH, Marsh R, Thomas AJ, Barnett NA, O'Brien JT. | Int Psychogeriatr. 2011 Feb;23(1):141-8. doi: 10.1017/S1041610210001250. Epub 2010 Jun 18. |
Sulfate ion patterns water at long distance. | O'Brien JT, Prell JS, Bush MF, Williams ER. | J Am Chem Soc. 2010 Jun 23;132(24):8248-9. doi: 10.1021/ja1024113. |
Hydration isomers of protonated phenylalanine and derivatives: relative stabilities from infrared photodissociation. | Prell JS, Chang TM, O'Brien JT, Williams ER. | J Am Chem Soc. 2010 Jun 9;132(22):7811-9. doi: 10.1021/ja102765w. |
Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension. | Firbank MJ, Narayan SK, Saxby BK, Ford GA, O'Brien JT. | Int Psychogeriatr. 2010 Aug;22(5):804-11. doi: 10.1017/S1041610210000499. Epub 2010 Apr 7. |
Depressive symptoms and cognitive decline in community-dwelling older adults. | Köhler S, van Boxtel MP, van Os J, Thomas AJ, O'Brien JT, Jolles J, Verhey FR, Allardyce J. | J Am Geriatr Soc. 2010 May;58(5):873-9. doi: 10.1111/j.1532-5415.2010.02807.x. Epub 2010 Mar 30. |
Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging. | Kenny ER, O'Brien JT, Cousins DA, Richardson J, Thomas AJ, Firbank MJ, Blamire AM. | Am J Geriatr Psychiatry. 2010 Jul;18(7):643-51. doi: 10.1097/JGP.0b013e3181cabd0e. |
IRPD spectroscopy and ensemble measurements: effects of different data acquisition and analysis methods. | Prell JS, O'Brien JT, Williams ER. | J Am Soc Mass Spectrom. 2010 May;21(5):800-9. doi: 10.1016/j.jasms.2010.01.010. Epub 2010 Jan 25. |
White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression. | Köhler S, Thomas AJ, Lloyd A, Barber R, Almeida OP, O'Brien JT. | Br J Psychiatry. 2010 Feb;196(2):143-9. doi: 10.1192/bjp.bp.109.071399. |
A study of orthostatic hypotension in late-life depression. | Richardson J, Kerr SR, Shaw F, Kenny RA, O'Brien JT, Thomas AJ. | Am J Geriatr Psychiatry. 2009 Nov;17(11):996-9. doi: 10.1097/JGP.0b013e3181b4bf35. |
Nicotinic 123I-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in Alzheimer's disease and dementia with Lewy bodies. | Colloby SJ, Perry EK, Pakrasi S, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT. | Am J Geriatr Psychiatry. 2010 Jan;18(1):86-90. doi: 10.1097/JGP.0b013e3181b972aa. |
Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer's disease, and dementia with Lewy bodies. | Ihara M, Polvikoski TM, Hall R, Slade JY, Perry RH, Oakley AE, Englund E, O'Brien JT, Ince PG, Kalaria RN. | Acta Neuropathol. 2010 May;119(5):579-89. doi: 10.1007/s00401-009-0635-8. Epub 2010 Jan 21. |
High resolution imaging of the medial temporal lobe in Alzheimer's disease and dementia with Lewy bodies. | Firbank MJ, Blamire AM, Teodorczuk A, Teper E, Burton EJ, Mitra D, O'Brien JT. | J Alzheimers Dis. 2010;21(4):1129-40. |
Covariance 99mTc-exametazime SPECT patterns in Alzheimer's disease and dementia with Lewy bodies: utility in differential diagnosis. | Colloby SJ, Taylor JP, Firbank MJ, McKeith IG, Williams ED, O'Brien JT. | J Geriatr Psychiatry Neurol. 2010 Mar;23(1):54-62. doi: 10.1177/0891988709355272. Epub 2009 Dec 22. |
Magnetic resonance imaging in lewy body dementias. | Watson R, Blamire AM, O'Brien JT. | Dement Geriatr Cogn Disord. 2009;28(6):493-506. doi: 10.1159/000264614. Epub 2009 Dec 8. Review. |
Top cited papers in International Psychogeriatrics: 6a. Quality of life for people with dementia living in residential and nursing home care: the impact of performance on activities of daily living, behavioral and psychological symptoms, language skills, and psychotropic drugs. | Ballard C, Margallo-Lana M, O'Brien JT, James I, Howard R, Fossey J. | Int Psychogeriatr. 2009 Dec;21(6):1026-30. doi: 10.1017/S1041610209990998. Epub 2009 Sep 22. No abstract available. |
Hydration of alkaline earth metal dications: effects of metal ion size determined using infrared action spectroscopy. | Bush MF, O'Brien JT, Prell JS, Wu CC, Saykally RJ, Williams ER. | J Am Chem Soc. 2009 Sep 23;131(37):13270-7. doi: 10.1021/ja901011x. |
Directly relating reduction energies of gaseous Eu(H2O)n(3+), n = 55-140, to aqueous solution: the absolute SHE potential and real proton solvation energy. | Donald WA, Leib RD, Demireva M, O'Brien JT, Prell JS, Williams ER. | J Am Chem Soc. 2009 Sep 23;131(37):13328-37. doi: 10.1021/ja902815v. |
Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study. | Teodorczuk A, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, Waldemar G, Schrotter G, Ferro JM, Chabriat H, Bazner H, Visser M, Inzitari D, O'Brien JT; LADIS Group.. | Psychol Med. 2010 Apr;40(4):603-10. doi: 10.1017/S0033291709990857. Epub 2009 Aug 12. |
The pattern and course of cognitive impairment in late-life depression. | Köhler S, Thomas AJ, Barnett NA, O'Brien JT. | Psychol Med. 2010 Apr;40(4):591-602. doi: 10.1017/S0033291709990833. Epub 2009 Aug 6. |
Structures of protonated dipeptides: the role of arginine in stabilizing salt bridges. | Prell JS, O'Brien JT, Steill JD, Oomens J, Williams ER. | J Am Chem Soc. 2009 Aug 19;131(32):11442-9. doi: 10.1021/ja901870d. |
Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy. | Donald WA, Leib RD, O'Brien JT, Williams ER. | Chemistry. 2009 Jun 8;15(24):5926-34. doi: 10.1002/chem.200900334. |
Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow. | Colloby SJ, Firbank MJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED, O'Brien JT. | Neurobiol Aging. 2011 Feb;32(2):293-301. doi: 10.1016/j.neurobiolaging.2009.02.005. Epub 2009 Mar 9. |
Changes in binding motif of protonated heterodimers containing valine and amines investigated using IRMPD spectroscopy between 800 and 3700 cm(-1) and theory. | O'Brien JT, Prell JS, Steill JD, Oomens J, Williams ER. | J Am Chem Soc. 2009 Mar 25;131(11):3905-12. doi: 10.1021/ja809928h. |
When should drug treatment be started for people with dementia? | Singh B, O'Brien JT. | Maturitas. 2009 Mar 20;62(3):230-4. doi: 10.1016/j.maturitas.2008.12.022. Epub 2009 Feb 6. Review. |
Levodopa use and sleep in patients with dementia with Lewy bodies. | Molloy S, Minett T, O'Brien JT, McKeith IG, Burn DJ. | Mov Disord. 2009 Mar 15;24(4):609-12. doi: 10.1002/mds.22411. |
Diagnostic accuracy of 123I-FP-CIT SPECT in possible dementia with Lewy bodies. | O'Brien JT, McKeith IG, Walker Z, Tatsch K, Booij J, Darcourt J, Marquardt M, Reininger C; DLB Study Group.. | Br J Psychiatry. 2009 Jan;194(1):34-9. doi: 10.1192/bjp.bp.108.052050. |
Microarray RNA expression analysis of cerebral white matter lesions reveals changes in multiple functional pathways. | Simpson JE, Hosny O, Wharton SB, Heath PR, Holden H, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Ince PG; Medical Research Council Cognitive Function and Ageing Study Neuropathology Group.. | Stroke. 2009 Feb;40(2):369-75. doi: 10.1161/STROKEAHA.108.529214. Epub 2008 Dec 24. |
Medial temporal lobe atrophy on MRI differentiates Alzheimer's disease from dementia with Lewy bodies and vascular cognitive impairment: a prospective study with pathological verification of diagnosis. | Burton EJ, Barber R, Mukaetova-Ladinska EB, Robson J, Perry RH, Jaros E, Kalaria RN, O'Brien JT. | Brain. 2009 Jan;132(Pt 1):195-203. doi: 10.1093/brain/awn298. Epub 2008 Nov 20. |
Interactions of mono- and divalent metal ions with aspartic and glutamic acid investigated with IR photodissociation spectroscopy and theory. | O'Brien JT, Prell JS, Steill JD, Oomens J, Williams ER. | J Phys Chem A. 2008 Oct 30;112(43):10823-30. doi: 10.1021/jp805787e. Epub 2008 Oct 2. |
A volumetric magnetic resonance imaging study of entorhinal cortex volume in dementia with lewy bodies. A comparison with Alzheimer's disease and Parkinson's disease with and without dementia. | Kenny ER, Burton EJ, O'Brien JT. | Dement Geriatr Cogn Disord. 2008;26(3):218-25. doi: 10.1159/000153432. Epub 2008 Sep 9. |
Electron capture by a hydrated gaseous peptide: effects of water on fragmentation and molecular survival. | Prell JS, O'Brien JT, Holm AI, Leib RD, Donald WA, Williams ER. | J Am Chem Soc. 2008 Sep 24;130(38):12680-9. doi: 10.1021/ja8022434. Epub 2008 Aug 30. |
A comparison of 99mTc-exametazime and 123I-FP-CIT SPECT imaging in the differential diagnosis of Alzheimer's disease and dementia with Lewy bodies. | Colloby SJ, Firbank MJ, Pakrasi S, Lloyd JJ, Driver I, McKeith IG, Williams ED, O'Brien JT. | Int Psychogeriatr. 2008 Dec;20(6):1124-40. doi: 10.1017/S1041610208007709. Epub 2008 Aug 27. |
A promising new treatment for Alzheimer's disease? | O'Brien JT. | Lancet Neurol. 2008 Sep;7(9):768-9. doi: 10.1016/S1474-4422(08)70177-7. No abstract available. |
Nanocalorimetry in mass spectrometry: a route to understanding ion and electron solvation. | Donald WA, Leib RD, O'Brien JT, Holm AI, Williams ER. | Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18102-7. doi: 10.1073/pnas.0801549105. Epub 2008 Aug 7. |
A comparison of neurocognitive impairment in younger and older adults with major depression. | Thomas AJ, Gallagher P, Robinson LJ, Porter RJ, Young AH, Ferrier IN, O'Brien JT. | Psychol Med. 2009 May;39(5):725-33. doi: 10.1017/S0033291708004042. Epub 2008 Jul 30. |
Poor attentional function predicts cognitive decline in patients with non-demented Parkinson's disease independent of motor phenotype. | Taylor JP, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ. | J Neurol Neurosurg Psychiatry. 2008 Dec;79(12):1318-23. doi: 10.1136/jnnp.2008.147629. Epub 2008 Jun 27. |
Hydration of gaseous copper dications probed by IR action spectroscopy. | O'Brien JT, Williams ER. | J Phys Chem A. 2008 Jul 3;112(26):5893-901. doi: 10.1021/jp7115643. Epub 2008 Jun 11. |
Vascular factors and depression. | Teper E, O'Brien JT. | Int J Geriatr Psychiatry. 2008 Oct;23(10):993-1000. doi: 10.1002/gps.2020. Review. |
Role of imaging techniques in the diagnosis of dementia. | O'Brien JT. | Br J Radiol. 2007 Dec;80 Spec No 2:S71-7. doi: 10.1259/bjr/33117326. Review. |
Effects of electron kinetic energy and ion-electron inelastic collisions in electron capture dissociation measured using ion nanocalorimetry. | O'Brien JT, Prell JS, Holm AI, Williams ER. | J Am Soc Mass Spectrom. 2008 Jun;19(6):772-9. doi: 10.1016/j.jasms.2008.02.010. Epub 2008 Mar 5. |
Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations. | O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. | Neuroimage. 2008 Apr 15;40(3):1056-63. doi: 10.1016/j.neuroimage.2008.01.010. Epub 2008 Jan 19. |
Absolute standard hydrogen electrode potential measured by reduction of aqueous nanodrops in the gas phase. | Donald WA, Leib RD, O'Brien JT, Bush MF, Williams ER. | J Am Chem Soc. 2008 Mar 19;130(11):3371-81. doi: 10.1021/ja073946i. Epub 2008 Feb 21. |
Depression and cognition in older adults. | Thomas AJ, O'Brien JT. | Curr Opin Psychiatry. 2008 Jan;21(1):8-13. doi: 10.1097/YCO.0b013e3282f2139b. Review. |
Microglial activation in white matter lesions and nonlesional white matter of ageing brains. | Simpson JE, Ince PG, Higham CE, Gelsthorpe CH, Fernando MS, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Stoeber K, Williams GH, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.. | Neuropathol Appl Neurobiol. 2007 Dec;33(6):670-83. |
Validation of a fully automated hippocampal segmentation method on patients with dementia. | Firbank MJ, Barber R, Burton EJ, O'Brien JT. | Hum Brain Mapp. 2008 Dec;29(12):1442-9. |
Donepezil for the treatment of agitation in Alzheimer's disease. | Howard RJ, Juszczak E, Ballard CG, Bentham P, Brown RG, Bullock R, Burns AS, Holmes C, Jacoby R, Johnson T, Knapp M, Lindesay J, O'Brien JT, Wilcock G, Katona C, Jones RW, DeCesare J, Rodger M; CALM-AD Trial Group.. | N Engl J Med. 2007 Oct 4;357(14):1382-92. |
White matter changes and late-life depressive symptoms: longitudinal study. | Teodorczuk A, O'Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund LO, Gouw A, Waldemar G, Schmidt R, Ferro JM, Chabriat H, Bäzner H, Inzitari D; LADIS Group.. | Br J Psychiatry. 2007 Sep;191:212-7. |
Reduction energy of 1 M aqueous ruthenium(III) hexaammine in the gas phase: a route toward establishing an absolute electrochemical scale. | Leib RD, Donald WA, O'Brien JT, Bush MF, Williams ER. | J Am Chem Soc. 2007 Jun 27;129(25):7716-7. Epub 2007 Jun 2. No abstract available. |
Nonergodicity in electron capture dissociation investigated using hydrated ion nanocalorimetry. | Leib RD, Donald WA, Bush MF, O'Brien JT, Williams ER. | J Am Soc Mass Spectrom. 2007 Jul;18(7):1217-31. Epub 2007 Apr 15. |
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies. | Ballard CG, Chalmers KA, Todd C, McKeith IG, O'Brien JT, Wilcock G, Love S, Perry EK. | Neurology. 2007 May 15;68(20):1726-9. |
Brain atrophy and white matter hyperintensity change in older adults and relationship to blood pressure. Brain atrophy, WMH change and blood pressure. | Firbank MJ, Wiseman RM, Burton EJ, Saxby BK, O'Brien JT, Ford GA. | J Neurol. 2007 Jun;254(6):713-21. Epub 2007 Apr 20. |
White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. | Simpson JE, Fernando MS, Clark L, Ince PG, Matthews F, Forster G, O'Brien JT, Barber R, Kalaria RN, Brayne C, Shaw PJ, Lewis CE, Wharton SB; MRC Cognitive Function and Ageing Neuropathology Study Group.. | Neuropathol Appl Neurobiol. 2007 Aug;33(4):410-9. Epub 2007 Apr 18. |
Atrophy is associated with posterior cingulate white matter disruption in dementia with Lewy bodies and Alzheimer's disease. | Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison R, O'Brien JT. | Neuroimage. 2007 May 15;36(1):1-7. Epub 2007 Feb 28. |
Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease. | Firbank MJ, Blamire AM, Krishnan MS, Teodorczuk A, English P, Gholkar A, Harrison RM, O'Brien JT. | Psychiatry Res. 2007 Jul 15;155(2):135-45. Epub 2007 Apr 3. |
Internal energy deposition in electron capture dissociation measured using hydrated divalent metal ions as nanocalorimeters. | Leib RD, Donald WA, Bush MF, O'brien JT, Williams ER. | J Am Chem Soc. 2007 Apr 25;129(16):4894-5. Epub 2007 Mar 30. No abstract available. |
Muscarinic acetylcholine receptor status in Alzheimer's disease assessed using (R, R) 123I-QNB SPECT. | Pakrasi S, Colloby SJ, Firbank MJ, Perry EK, Wyper DJ, Owens J, McKeith IG, Williams ED, O'Brien JT. | J Neurol. 2007 Jul;254(7):907-13. Epub 2007 Mar 14. |
Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies. | Taylor JP, Colloby SJ, McKeith IG, Burn DJ, Williams D, Patterson J, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2007 Oct;78(10):1069-71. Epub 2007 Feb 13. |
Infrared spectroscopy of cationized arginine in the gas phase: direct evidence for the transition from nonzwitterionic to zwitterionic structure. | Bush MF, O'Brien JT, Prell JS, Saykally RJ, Williams ER. | J Am Chem Soc. 2007 Feb 14;129(6):1612-22. Epub 2007 Jan 24. |
Soluble cell adhesion molecules in late-life depression. | Thomas AJ, Morris C, Davis S, Jackson E, Harrison R, O'Brien JT. | Int Psychogeriatr. 2007 Oct;19(5):914-20. Epub 2007 Jan 4. |
Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies. | Rowan E, McKeith IG, Saxby BK, O'Brien JT, Burn D, Mosimann U, Newby J, Daniel S, Sanders J, Wesnes K. | Dement Geriatr Cogn Disord. 2007;23(3):161-7. Epub 2006 Dec 28. |
Introduction: for debate: should neuroimaging be a routine investigation in all cases of suspected dementia? | O'Brien JT. | Int Psychogeriatr. 2007 Jun;19(3):525-6. Epub 2006 Dec 19. No abstract available. |
Alpha4beta2 nicotinic receptor status in Alzheimer's disease using 123I-5IA-85380 single-photon-emission computed tomography. | O'Brien JT, Colloby SJ, Pakrasi S, Perry EK, Pimlott SL, Wyper DJ, McKeith IG, Williams ED. | J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):356-62. Epub 2006 Nov 29. |
NICE and anti-dementia drugs: a triumph of health economics over clinical wisdom? | O'Brien JT. | Lancet Neurol. 2006 Dec;5(12):994-6. No abstract available. |
Subjectively reported sleep quality and excessive daytime somnolence in Parkinson's disease with and without dementia, dementia with Lewy bodies and Alzheimer's disease. | Boddy F, Rowan EN, Lett D, O'Brien JT, McKeith IG, Burn DJ. | Int J Geriatr Psychiatry. 2007 Jun;22(6):529-35. |
Progression of white matter hyperintensities in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia: a comparison with normal aging. | Burton EJ, McKeith IG, Burn DJ, Firbank MJ, O'Brien JT. | Am J Geriatr Psychiatry. 2006 Oct;14(10):842-9. |
White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study. | O'Brien JT, Firbank MJ, Krishnan MS, van Straaten EC, van der Flier WM, Petrovic K, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, Inzitari D; LADIS Group.. | Am J Geriatr Psychiatry. 2006 Oct;14(10):834-41. |
In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia. | Colloby SJ, Pakrasi S, Firbank MJ, Perry EK, Piggott MA, Owens J, Wyper DJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. | Neuroimage. 2006 Nov 1;33(2):423-9. Epub 2006 Sep 7. |
Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study. | Krishnan MS, O'Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A, Wahlund LO, Scheltens P, van Straaten EC, Inzitari D; LADIS Group.. | Int J Geriatr Psychiatry. 2006 Oct;21(10):983-9. |
Effect of levodopa on cognitive function in Parkinson's disease with and without dementia and dementia with Lewy bodies. | Molloy SA, Rowan EN, O'Brien JT, McKeith IG, Wesnes K, Burn DJ. | J Neurol Neurosurg Psychiatry. 2006 Dec;77(12):1323-8. Epub 2006 Sep 4. |
Vascular cognitive impairment. | O'Brien JT. | Am J Geriatr Psychiatry. 2006 Sep;14(9):724-33. Review. |
Medial temporal atrophy rather than white matter hyperintensities predict cognitive decline in stroke survivors. | Firbank MJ, Burton EJ, Barber R, Stephens S, Kenny RA, Ballard C, Kalaria RN, O'Brien JT. | Neurobiol Aging. 2007 Nov;28(11):1664-9. Epub 2006 Aug 24. |
Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop? | Pakrasi S, Thomas A, Mosimann UP, Cousins DA, Lett D, Burn DJ, O'Brien JT, McKeith IG. | Int J Geriatr Psychiatry. 2006 Aug;21(8):719-21. |
Structures of lithiated lysine and structural analogues in the gas phase: effects of water and proton affinity on zwitterionic stability. | Lemoff AS, Bush MF, O'Brien JT, Williams ER. | J Phys Chem A. 2006 Jul 13;110(27):8433-42. |
More severe functional impairment in dementia with lewy bodies than Alzheimer disease is related to extrapyramidal motor dysfunction. | McKeith IG, Rowan E, Askew K, Naidu A, Allan L, Barnett N, Lett D, Mosimann UP, Burn D, O'Brien JT. | Am J Geriatr Psychiatry. 2006 Jul;14(7):582-8. |
A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression. | Thomas AJ, Hendriksen M, Piggott M, Ferrier IN, Perry E, Ince P, O'Brien JT. | Neuropathol Appl Neurobiol. 2006 Jun;32(3):296-303. |
White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. | Fernando MS, Simpson JE, Matthews F, Brayne C, Lewis CE, Barber R, Kalaria RN, Forster G, Esteves F, Wharton SB, Shaw PJ, O'Brien JT, Ince PG; MRC Cognitive Function and Ageing Neuropathology Study Group.. | Stroke. 2006 Jun;37(6):1391-8. Epub 2006 Apr 20. |
Motor subtype and cognitive decline in Parkinson's disease, Parkinson's disease with dementia, and dementia with Lewy bodies. | Burn DJ, Rowan EN, Allan LM, Molloy S, O'Brien JT, McKeith IG. | J Neurol Neurosurg Psychiatry. 2006 May;77(5):585-9. |
Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly. | Porter RJ, Gallagher P, O'Brien JT. | J Psychopharmacol. 2007 Jan;21(1):71-5. Epub 2006 Mar 13. |
Depression and comorbidity. | O'Brien JT. | Am J Geriatr Psychiatry. 2006 Mar;14(3):187-90. No abstract available. |
A periodically active pulsar giving insight into magnetospheric physics. | Kramer M, Lyne AG, O'Brien JT, Jordan CA, Lorimer DR. | Science. 2006 Apr 28;312(5773):549-51. Epub 2006 Feb 23. |
Transient radio bursts from rotating neutron stars. | McLaughlin MA, Lyne AG, Lorimer DR, Kramer M, Faulkner AJ, Manchester RN, Cordes JM, Camilo F, Possenti A, Stairs IH, Hobbs G, D'Amico N, Burgay M, O'Brien JT. | Nature. 2006 Feb 16;439(7078):817-20. |
Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies. | Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, Burn DJ, McKeith IG. | Am J Geriatr Psychiatry. 2006 Feb;14(2):153-60. |
Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. | McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, et al. | Neurology. 2005 Dec 27;65(12):1863-72. Epub 2005 Oct 19. Review. Erratum in: Neurology. 2005 Dec 27;65(12):1992. |
Longitudinal change in 99mTcHMPAO cerebral perfusion SPECT in Parkinson's disease over one year. | Firbank MJ, Molloy S, McKeith IG, Burn DJ, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2005 Oct;76(10):1448-51. |
Is peri-operative cortisol secretion related to post-operative cognitive dysfunction? | Rasmussen LS, O'Brien JT, Silverstein JH, Johnson TW, Siersma VD, Canet J, Jolles J, Hanning CD, Kuipers HM, Abildstrom H, Papaioannou A, Raeder J, Yli-Hankala A, Sneyd JR, Munoz L, Moller JT; ISPOCD2 Investigators.. | Acta Anaesthesiol Scand. 2005 Oct;49(9):1225-31. |
Brain atrophy rates in Parkinson's disease with and without dementia using serial magnetic resonance imaging. | Burton EJ, McKeith IG, Burn DJ, O'Brien JT. | Mov Disord. 2005 Dec;20(12):1571-6. |
The role of levodopa in the management of dementia with Lewy bodies. | Molloy S, McKeith IG, O'Brien JT, Burn DJ. | J Neurol Neurosurg Psychiatry. 2005 Sep;76(9):1200-3. |
Subjective memory complaints, white-matter lesions, depressive symptoms, and cognition in elderly patients. | Minett TS, Dean JL, Firbank M, English P, O'Brien JT. | Am J Geriatr Psychiatry. 2005 Aug;13(8):665-71. |
Longitudinal study of cerebral blood flow SPECT in Parkinson's disease with dementia, and dementia with Lewy bodies. | Firbank MJ, Burn DJ, McKeith IG, O'Brien JT. | Int J Geriatr Psychiatry. 2005 Aug;20(8):776-82. |
White matter hyperintensities and depression--preliminary results from the LADIS study. | Firbank MJ, O'Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund LO, van Straaten I, Inzitari D. | Int J Geriatr Psychiatry. 2005 Jul;20(7):674-9. |
Effects of acute tryptophan depletion on mood and cognitive functioning in older recovered depressed subjects. | Porter RJ, Phipps AJ, Gallagher P, Scott A, Stevenson PS, O'Brien JT. | Am J Geriatr Psychiatry. 2005 Jul;13(7):607-15. |
Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies. | O'Brien JT, Firbank MJ, Mosimann UP, Burn DJ, McKeith IG. | Psychiatry Res. 2005 Jul 30;139(2):79-88. |
Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson's disease with and without dementia assessed using 123I-FP-CIT SPECT. | Colloby SJ, Williams ED, Burn DJ, Lloyd JJ, McKeith IG, O'Brien JT. | Eur J Nucl Med Mol Imaging. 2005 Oct;32(10):1176-85. Epub 2005 Jun 2. |
Neuroleptic sensitivity in Parkinson's disease and parkinsonian dementias. | Aarsland D, Perry R, Larsen JP, McKeith IG, O'Brien JT, Perry EK, Burn D, Ballard CG. | J Clin Psychiatry. 2005 May;66(5):633-7. |
Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies. | Mosimann UP, Müri RM, Burn DJ, Felblinger J, O'Brien JT, McKeith IG. | Brain. 2005 Jun;128(Pt 6):1267-76. Epub 2005 Mar 17. |
Temporal lobe atrophy on MRI in Parkinson disease with dementia: a comparison with Alzheimer disease and dementia with Lewy bodies. | Tam CW, Burton EJ, McKeith IG, Burn DJ, O'Brien JT. | Neurology. 2005 Mar 8;64(5):861-5. |
Emission tomography in dementia. | Pakrasi S, O'Brien JT. | Nucl Med Commun. 2005 Mar;26(3):189-96. Review. |
Onset of asymptotic scaling in deuteron photodisintegration. | Rossi P, Mirazita M, Ronchetti F, De Sanctis E, Adams G, Ambrozewicz P, Anciant E, Anghinolfi M, Asavapibhop B, Audit G, Avakian H, Bagdasaryan H, Ball JP, Barrow S, Battaglieri M, Beard K, Bektasoglu M, Bellis M, Benmouna N, Berman BL, Bertozzi W, Bianchi N, et al. | Phys Rev Lett. 2005 Jan 14;94(1):012301. Epub 2005 Jan 6. |
Increase in interleukin-1beta in late-life depression. | Thomas AJ, Davis S, Morris C, Jackson E, Harrison R, O'Brien JT. | Am J Psychiatry. 2005 Jan;162(1):175-7. |
Visual perception in Parkinson disease dementia and dementia with Lewy bodies. | Mosimann UP, Mather G, Wesnes KA, O'Brien JT, Burn DJ, McKeith IG. | Neurology. 2004 Dec 14;63(11):2091-6. |
Hippocampal atrophy, whole brain volume, and white matter lesions in older hypertensive subjects. | Wiseman RM, Saxby BK, Burton EJ, Barber R, Ford GA, O'Brien JT. | Neurology. 2004 Nov 23;63(10):1892-7. |
A volumetric study of MRI signal hyperintensities in late-life depression. | Firbank MJ, Lloyd AJ, Ferrier N, O'Brien JT. | Am J Geriatr Psychiatry. 2004 Nov-Dec;12(6):606-12. |
The application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease. | Colloby SJ, O'Brien JT, Fenwick JD, Firbank MJ, Burn DJ, McKeith IG, Williams ED. | Neuroimage. 2004 Nov;23(3):956-66. |
A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. | O'Brien JT, Lloyd A, McKeith I, Gholkar A, Ferrier N. | Am J Psychiatry. 2004 Nov;161(11):2081-90. |
APOE epsilon4 and cognitive decline in older stroke patients with early cognitive impairment. | Ballard CG, Morris CM, Rao H, O'Brien JT, Barber R, Stephens S, Rowan E, Gibson A, Kalaria RN, Kenny RA. | Neurology. 2004 Oct 26;63(8):1399-402. |
NINDS AIREN neuroimaging criteria do not distinguish stroke patients with and without dementia. | Ballard CG, Burton EJ, Barber R, Stephens S, Kenny RA, Kalaria RN, O'Brien JT. | Neurology. 2004 Sep 28;63(6):983-8. |
Comparing gray matter loss profiles between dementia with Lewy bodies and Alzheimer's disease using cortical pattern matching: diagnosis and gender effects. | Ballmaier M, O'Brien JT, Burton EJ, Thompson PM, Rex DE, Narr KL, McKeith IG, DeLuca H, Toga AW. | Neuroimage. 2004 Sep;23(1):325-35. |
Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain. | Fernando MS, O'Brien JT, Perry RH, English P, Forster G, McMeekin W, Slade JY, Golkhar A, Matthews FE, Barber R, Kalaria RN, Ince PG; Neuropathology Group of MRC CFAS.. | Neuropathol Appl Neurobiol. 2004 Aug;30(4):385-95. |
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies. | O'Brien JT, Colloby S, Fenwick J, Williams ED, Firbank M, Burn D, Aarsland D, McKeith IG. | Arch Neurol. 2004 Jun;61(6):919-25. |
Carotid sinus syndrome is common in dementia with Lewy bodies and correlates with deep white matter lesions. | Kenny RA, Shaw FE, O'Brien JT, Scheltens PH, Kalaria R, Ballard C. | J Neurol Neurosurg Psychiatry. 2004 Jul;75(7):966-71. |
Hippocampal volume change in depression: late- and early-onset illness compared. | Lloyd AJ, Ferrier IN, Barber R, Gholkar A, Young AH, O'Brien JT. | Br J Psychiatry. 2004 Jun;184:488-95. |
Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression. | Hendricksen M, Thomas AJ, Ferrier IN, Ince P, O'Brien JT. | Am J Psychiatry. 2004 Jun;161(6):1096-102. |
Neuropathological substrates of psychiatric symptoms in prospectively studied patients with autopsy-confirmed dementia with lewy bodies. | Ballard CG, Jacoby R, Del Ser T, Khan MN, Munoz DG, Holmes C, Nagy Z, Perry EK, Joachim C, Jaros E, O'Brien JT, Perry RH, McKeith IG. | Am J Psychiatry. 2004 May;161(5):843-9. |
Depression and vascular disease: what is the relationship? | Thomas AJ, Kalaria RN, O'Brien JT. | J Affect Disord. 2004 Apr;79(1-3):81-95. Review. |
Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder. | Thomas AJ, Davis S, Ferrier IN, Kalaria RN, O'Brien JT. | Biol Psychiatry. 2004 Mar 15;55(6):652-5. |
Observation of an exotic baryon with S=+1 in photoproduction from the proton. | Kubarovsky V, Guo L, Weygand DP, Stoler P, Battaglieri M, DeVita R, Adams G, Li J, Nozar M, Salgado C, Ambrozewicz P, Anciant E, Anghinolfi M, Asavapibhop B, Audit G, Auger T, Avakian H, Bagdasaryan H, Ball JP, Barrow S, Beard K, Bektasoglu M, et al. | Phys Rev Lett. 2004 Jan 23;92(3):032001. Epub 2004 Jan 21. |
Cerebral atrophy in Parkinson's disease with and without dementia: a comparison with Alzheimer's disease, dementia with Lewy bodies and controls. | Burton EJ, McKeith IG, Burn DJ, Williams ED, O'Brien JT. | Brain. 2004 Apr;127(Pt 4):791-800. Epub 2004 Jan 28. |
A 3-month, randomized, placebo-controlled, neuroleptic discontinuation study in 100 people with dementia: the neuropsychiatric inventory median cutoff is a predictor of clinical outcome. | Ballard CG, Thomas A, Fossey J, Lee L, Jacoby R, Lana MM, Bannister C, McShane R, Swann A, Juszczak E, O'Brien JT. | J Clin Psychiatry. 2004 Jan;65(1):114-9. |
Measurement of the proton spin structure function g1(x,Q2) for Q2 from 0.15 to 1.6 GeV2 with CLAS. | Fatemi R, Skabelin AV, Burkert VD, Crabb D, De Vita R, Kuhn SE, Minehart R, Adams G, Anciant E, Anghinolfi M, Asavapibhop B, Audit G, Auger T, Avakian H, Bagdasaryan H, Ball JP, Barrow S, Battaglieri M, Beard K, Bektasoglu M, Bellis M, Bertozzi W, et al. | Phys Rev Lett. 2003 Nov 28;91(22):222002. Epub 2003 Nov 25. |
The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia. | Paling SM, Williams ED, Barber R, Burton EJ, Crum WR, Fox NC, O'Brien JT. | Med Image Anal. 2004 Mar;8(1):69-79. |
Atrophy of the putamen in dementia with Lewy bodies but not Alzheimer's disease: an MRI study. | Cousins DA, Burton EJ, Burn D, Gholkar A, McKeith IG, O'Brien JT. | Neurology. 2003 Nov 11;61(9):1191-5. |
Regional cerebral blood flow in Parkinson's disease with and without dementia. | Firbank MJ, Colloby SJ, Burn DJ, McKeith IG, O'Brien JT. | Neuroimage. 2003 Oct;20(2):1309-19. |
Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects. | Firbank MJ, Minett T, O'Brien JT. | Neurology. 2003 Oct 14;61(7):950-4. |
Clinical predictors of response to Acetyl Cholinesterase Inhibitors: experience from routine clinical use in Newcastle. | Pakrasi S, Mukaetova-Ladinska EB, McKeith IG, O'Brien JT. | Int J Geriatr Psychiatry. 2003 Oct;18(10):879-86. |
Use of functional imaging in Parkinsonism and dementia. | Burn DJ, O'Brien JT. | Mov Disord. 2003 Sep;18 Suppl 6:S88-95. Review. |
A neuropathological study of periventricular white matter hyperintensities in major depression. | Thomas AJ, O'Brien JT, Barber R, McMeekin W, Perry R. | J Affect Disord. 2003 Sep;76(1-3):49-54. |
Extrapyramidal features in Parkinson's disease with and without dementia and dementia with Lewy bodies: A cross-sectional comparative study. | Burn DJ, Rowan EN, Minett T, Sanders J, Myint P, Richardson J, Thomas A, Newby J, Reid J, O'Brien JT, McKeith IG. | Mov Disord. 2003 Aug;18(8):884-9. |
Vascular cognitive impairment. | O'Brien JT, Erkinjuntti T, Reisberg B, Roman G, Sawada T, Pantoni L, Bowler JV, Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST. | Lancet Neurol. 2003 Feb;2(2):89-98. Review. |
A prospectively studied clinicopathological case of 'vascular depression'. | O'Brien JT, Thomas A, English P, Perry R, Jaros E. | Int J Geriatr Psychiatry. 2003 Jul;18(7):656-7. No abstract available. |
Association of life events and psychosocial factors with early but not late onset depression in the elderly: implications for possible differences in aetiology. | Grace J, O'Brien JT. | Int J Geriatr Psychiatry. 2003 Jun;18(6):473-8. |
Depression with late onset is associated with right frontal lobe atrophy. | Almeida OP, Burton EJ, Ferrier N, McKeith IG, O'Brien JT. | Psychol Med. 2003 May;33(4):675-81. |
MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease. | Almeida OP, Burton EJ, McKeith I, Gholkar A, Burn D, O'Brien JT. | Dement Geriatr Cogn Disord. 2003;16(2):57-63. |
A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry. | Karas GB, Burton EJ, Rombouts SA, van Schijndel RA, O'Brien JT, Scheltens Ph, McKeith IG, Williams D, Ballard C, Barkhof F. | Neuroimage. 2003 Apr;18(4):895-907. |
Regulation of attention and response to therapy in dementia by butyrylcholinesterase. | O'Brien KK, Saxby BK, Ballard CG, Grace J, Harrington F, Ford GA, O'Brien JT, Swan AG, Fairbairn AF, Wesnes K, del Ser T, Edwardson JA, Morris CM, McKeith IG. | Pharmacogenetics. 2003 Apr;13(4):231-9. |
Photoproduction of the omega meson on the proton at large momentum transfer. | Battaglieri M, Brunoldi M, De Vita R, Laget JM, Osipenko M, Ripani M, Taiuti M, Adams G, Amaryan MJ, Anciant E, Anghinolfi M, Armstrong DS, Asavapibhop B, Asryan G, Audit G, Auger T, Avakian H, Barrow S, Beard K, Bektasoglu M, Berman BL, Bersani A, et al. | Phys Rev Lett. 2003 Jan 17;90(2):022002. Epub 2003 Jan 16. |
Dementia with Lewy bodies. | McKeith IG, Burn DJ, Ballard CG, Collerton D, Jaros E, Morris CM, McLaren A, Perry EK, Perry R, Piggott MA, O'Brien JT. | Semin Clin Neuropsychiatry. 2003 Jan;8(1):46-57. Review. |
Effects of acute tryptophan depletion on cognitive function in Alzheimer's disease and in the healthy elderly. | Porter RJ, Lunn BS, O'Brien JT. | Psychol Med. 2003 Jan;33(1):41-9. |
Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression. | Thomas AJ, Perry R, Kalaria RN, Oakley A, McMeekin W, O'Brien JT. | Int J Geriatr Psychiatry. 2003 Jan;18(1):7-13. |
Cognitive associations of subcortical white matter lesions in older people. | O'Brien JT, Wiseman R, Burton EJ, Barber B, Wesnes K, Saxby B, Ford GA. | Ann N Y Acad Sci. 2002 Nov;977:436-44. |
Pathologies and pathological mechanisms for white matter hyperintensities in depression. | Thomas AJ, Perry R, Barber R, Kalaria RN, O'Brien JT. | Ann N Y Acad Sci. 2002 Nov;977:333-9. |
Memory clinics and clinical governance--a UK perspective. | Phipps AJ, O'Brien JT. | Int J Geriatr Psychiatry. 2002 Dec;17(12):1128-32. |
Glial fibrillary acidic protein in late life major depressive disorder: an immunocytochemical study. | Davis S, Thomas A, Perry R, Oakley A, Kalaria RN, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2002 Nov;73(5):556-60. |
Patterns of cerebral atrophy in dementia with Lewy bodies using voxel-based morphometry. | Burton EJ, Karas G, Paling SM, Barber R, Williams ED, Ballard CG, McKeith IG, Scheltens P, Barkhof F, O'Brien JT. | Neuroimage. 2002 Oct;17(2):618-30. |
Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. | Thomas AJ, O'Brien JT, Davis S, Ballard C, Barber R, Kalaria RN, Perry RH. | Arch Gen Psychiatry. 2002 Sep;59(9):785-92. |
Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. | Thomas AJ, Ferrier IN, Kalaria RN, Davis S, O'Brien JT. | Br J Psychiatry. 2002 Aug;181:129-34. |
A comprehensive review of proton magnetic resonance spectroscopy studies in dementia and Parkinson's disease. | Firbank MJ, Harrison RM, O'Brien JT. | Dement Geriatr Cogn Disord. 2002;14(2):64-76. Review. |
Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa. | Ballard CG, O'Brien JT, Reichelt K, Perry EK. | J Clin Psychiatry. 2002 Jul;63(7):553-8. |
A comparison of (99m)Tc-HMPAO SPET changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping. | Colloby SJ, Fenwick JD, Williams ED, Paling SM, Lobotesis K, Ballard C, McKeith I, O'Brien JT. | Eur J Nucl Med Mol Imaging. 2002 May;29(5):615-22. Epub 2002 Mar 5. |
Effects of rapid tryptophan depletion on salivary and plasma cortisol in Alzheimer's disease and the healthy elderly. | Porter RJ, Marshall EF, O'Brien JT. | J Psychopharmacol. 2002 Mar;16(1):73-8. |
Effects of hydrocortisone administration on cognitive function in the elderly. | Porter RJ, Barnett NA, Idey A, McGuckin EA, O'Brien JT. | J Psychopharmacol. 2002 Mar;16(1):65-71. |
Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies. | Court JA, Ballard CG, Piggott MA, Johnson M, O'Brien JT, Holmes C, Cairns N, Lantos P, Perry RH, Jaros E, Perry EK. | Pharmacol Biochem Behav. 2001 Dec;70(4):571-9. |
Dementia with Lewy bodies and AD are not associated with occipital lobe atrophy on MRI. | Middelkoop HA, van der Flier WM, Burton EJ, Lloyd AJ, Paling S, Barber R, Ballard C, McKeith IG, O'Brien JT. | Neurology. 2001 Dec 11;57(11):2117-20. |
Combined magnetic resonance imaging and single-photon emission tomography scanning in the discrimination of Alzheimer's disease from age-matched controls. | O'Brien JT, Ames D, Desmond P, Lichtenstein M, Binns D, Schweitzer I, Davis S, Tress B. | Int Psychogeriatr. 2001 Jun;13(2):149-61. |
Drugs for Alzheimer's disease. | O'Brien JT, Ballard CG. | BMJ. 2001 Jul 21;323(7305):123-4. No abstract available. |
Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia. | O'Brien JT, Paling S, Barber R, Williams ED, Ballard C, McKeith IG, Gholkar A, Crum WR, Rossor MN, Fox NC. | Neurology. 2001 May 22;56(10):1386-8. |
Is apolipoprotein e4 associated with cognitive decline in depression? | Jackson EJ, Rajah S, Morris C, Ballard C, Thomas AJ, O'Brien JT. | Int J Geriatr Psychiatry. 2001 Apr;16(4):436-7. No abstract available. |
Depression in late life, cognitive decline and white matter pathology in two clinico-pathologically investigated cases. | Lloyd AJ, Grace JB, Jaros E, Perry RH, Fairbairn AF, Swann AG, O'Brien JT, McKeith IG. | Int J Geriatr Psychiatry. 2001 Mar;16(3):281-7. |
Multiple substrates of late-onset dementia: implications for brain protection. | Kalaria RN, Ballard CG, Ince PG, Kenny RA, McKeith IG, Morris CM, O'Brien JT, Perry EK, Perry RH, Edwardson JA. | Novartis Found Symp. 2001;235:49-60; discussion 60-5. Review. |
Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD. | Lobotesis K, Fenwick JD, Phipps A, Ryman A, Swann A, Ballard C, McKeith IG, O'Brien JT. | Neurology. 2001 Mar 13;56(5):643-9. |
A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study. | Barber R, McKeith IG, Ballard C, Gholkar A, O'Brien JT. | Dement Geriatr Cogn Disord. 2001 May-Jun;12(3):198-205. |
The natural history of psychosis and depression in dementia with Lewy bodies and Alzheimer's disease: persistence and new cases over 1 year of follow-up. | Ballard CG, O'Brien JT, Swann AG, Thompson P, Neill D, McKeith IG. | J Clin Psychiatry. 2001 Jan;62(1):46-9. |
A neuropathological study of vascular factors in late-life depression. | Thomas AJ, Ferrier IN, Kalaria RN, Perry RH, Brown A, O'Brien JT. | J Neurol Neurosurg Psychiatry. 2001 Jan;70(1):83-7. |