Funded by The Lewy Body Society, Addenbrooke’s Charitable Trust, and Alzheimer’s Research UK, and led by Drs Li Su and John O’Brien, the Multimodal Imaging in Lewy Body Disorders (MILOS) project aims to detect the damage to brain structure and function associated with Lewy Body Disorder.

We combine multiple state-of-the-art neuroimaging and computational techniques in this three years project in the University of Cambridge. First, we use Magnetoencephalography (MEG), to detect and measure electrical activity in the brain. Second, magnetic resonance imaging (MRI) is used to measure changes in brain structure. Third, Positron Emission Tomography (PET) will be used to detect damaged protein (amyloid beta using the well-established PIB radioligand) in living brains that are indicative of pathology associated with Alzheimer’s disease.

The findings will further our understanding on how DLB affects the patient’s brain, in particular the causes of cognitive decline and psychiatric symptoms, and how to detect this condition and treat it in the future.