Professor Ed Bullmore
Professor of Psychiatry
Deputy Head, School of Clinical Medicine
Director, Wolfson Brain Imaging Centre
Director of R&D, Cambridgeshire & Peterborough NHS Foundation Trust
I have been part of the University of Cambridge since 1999, and I still think it’s one of the best places in the world to work! My own research has focused for many years on neuroimaging and methods for the analysis of brain connectivity and networks, with major applications to adolescent brain development and understanding of mental health disorders. For the last seven years or so, I have also become increasingly interested in the role that the immune system may play in depression and anti-depressant drug development. I have enjoyed being Head of the Department of Psychiatry, and encouraging our continued growth and increasingly high profile, since 2014. I am convinced that the best is yet to come for advances in mental health and neuroscience globally – and that Cambridge is in a strong position to make a major contribution to the next generation of progress.
Brain Mapping Unit
Neuroscience in Psychiatry Network
Lynall M-E, Turner L, Bhatti J, Cavanagh J, de Boer P, Mondelli V, Jones D, Drevets W.C., Cowen P, Harrison N.A., Pariante C.M., Pointon L., NIMA Consortium, Clatworthy M.R., Bullmore E.T. (2020) “Peripheral blood cell-stratified subgroups of inflamed depression” Biological Psychiatry https://doi.org/10.1016/j.biopsych.2019.11.017 Focus of an invited commentary https://doi.org/10.1016/j.biopsych.2020.04.024
Analyzing the relationships between dimensions of depression and white blood cell counts. Depression was associated “on average” with increased blood cell counts – in 14 cell classes, compared to non-depressed volunteers. Individual differences in depressive symptom severity, anxiety, recent stress exposure, and BMI, were also associated with peripheral immune cell counts.
Romero-Garcia R, Seidlitz J, Whitaker KJ, Morgan SE, Fonagy P, Dolan RJ, Jones PB, Goodyer IM, Suckling J, Vértes PE, NSPN Consortium, Bullmore ET (2020) “Schizotypy-related magnetization of cortex in healthy adolescence is co-located with expression of schizophrenia-related genes” Biological Psychiatry https://doi.org/10.1016/j.biopsych.2019.12.005 Focus of an invited commentary https://doi.org/10.1016/j.biopsych.2020.05.016
Adolescent brain development and schizotypy. Micro-structural MRI (MT), indicative of cortical myelination, was increased in regions of the default mode network in healthy young people (14-25 years) with high scores on the schizotypy personality questionnaire (SPQ). Schizotypy is a complex personality trait associated with schizophrenia, and this posterior medial cortical area of schizotypy-related myelination was co-located with enriched expression of genes associated with schizophrenia by prior GWAS studies.