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Psychiatry

 

Mary-Ellen leads the Cambridge–Oxford BioMind Laboratory, which investigates the brain–immune interface in psychiatric illness.

We use translational approaches that integrate bioinformatics and wet-lab methods to uncover mechanisms, biomarkers, and therapeutic targets. Our work spans immunogenetics, immunophenotyping, and high-throughput functional genomics, including single-cell and proteomic technologies applied to blood samples from patient cohorts and population studies. A particular focus is on understanding how psychiatric risk variants contribute to immunopathogenesis.

We offer a collaborative, interdisciplinary team environment at the intersection of neuroscience, immunology, and genetics, with opportunities to build expertise in cutting-edge computational and experimental methods while advancing understanding of psychiatric disease mechanisms. CONACYT scholars and Chinese Scholarship Council students are encouraged to apply.

 

 

Publications

Key publications: 

Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells.

DOI: http://doi.org/10.1038/s41467-022-33885-7
Journal: Nature Communications
E-pub date: 15 Oct 2022
Authors: M-E Lynall, B Soskic, J Hayhurst, J Schwartzentruber, DF Levey, GA Pathak, R Polimanti, J Gelernter, MB Stein, G Trynka, MR Clatworthy, E Bullmore

 

B-cells are abnormal in psychosocial stress and regulate meningeal myeloid cell activation.

DOI: http://doi.org/10.1016/j.bbi.2021.08.002
Journal: Brain Behav Immun
E-pub date: 1 Oct 2021
Authors: M-E Lynall, SL Kigar, ML Lehmann, AE DePuyt, ZK Tuong, SJ Listwak, AG Elkahloun, ET Bullmore, M Herkenham, MR Clatworthy

 

Peripheral Blood Cell-Stratified Subgroups of Inflamed Depression.

DOI: http://doi.org/10.1016/j.biopsych.2019.11.017
Journal: Biol Psychiatry
E-pub date: 15 Jul 2020
Authors: M-E Lynall, L Turner, J Bhatti, J Cavanagh, P de Boer, V Mondelli, D Jones, WC Drevets, P Cowen, NA Harrison, CM Pariante, L Pointon, MR Clatworthy, E Bullmore, Neuroimmunology of Mood Disorders and Alzheimer’s Disease (NIMA) Consortium

NIHR Clinical Lecturer in General Psychiatry
Takes PhD students
Not available for consultancy

Affiliations

Classifications: