Research Group: Old Age Psychiatry
Biography
I am a Race Against Dementia Fellow studying the role of cerebrovascular dysfunction in dementia and cognitive impairment, with the help of multimodal neuroimaging techniques and clinical data in humans. Currently, my research focuses on identifying early predictors and markers of dementia, and how cerebral small vessel disease is involved in early dementia pathogenesis. As part of this, I examine markers of cerebral small vessel disease and cerebrovascular health in relation to other brain pathologies like inflammation and blood brain barrier permeability, as well as established dementia risk factors. Altogether, my research aims to further our understanding of how various pathologies interact in their contribution to neurodegeneration and clinical outcomes. On top of my academic work, I support younger researchers as the Early Career Investigator Representative of the International Society of Vascular Behavioural and Cognitive Disorders (VasCog) (https://www.vascog.org/).
Publications
Low A, Mak E, Rowe JB, Markus HS, O’Brien JT. 'Inflammation and cerebral small vessel disease: A systematic review.' Ageing Res Rev. 2019; 53:100916. doi: 10.1016/j.arr.2019.100916.
Low A, McKiernan E, Prats-Sedano MA, Carter SF, Stefaniak JD, Su L, Dounavi ME, Muniz-Terrera G, Jenkins N, Bridgeman K, Ritchie K, Lawlor B, Naci L, Malhotra P, Mackay C, Koychev I, Thayanandan T, Raymont V, Ritchie CW, Stewart W, O’Brien JT. 'Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study.' JAMA Netw Open. 2024 Aug 1;7(8):e2426774. doi: 10.1001/jamanetworkopen.2024.26774.
Low A, Mak E, Malpetti M, Passamonti L, Nicastro N, Stefaniak JD, Savulich G, Chouliaras L, Su L, Rowe JB, Markus HS, O’Brien JT. 'In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.' J Neurol Neurosurg Psychiatry. 2020; 11;92(1):45-52. doi: 10.1136/jnnp-2020-323894.
Low A, Prats-Sedano M, McKiernan E, Carter S, Stefaniak JD, Nannoni S, Su L, Dounavi ME, Muniz-Terrera G, Ritchie K, Lawlor B, Naci L, Malhotra P, MacKay C, Koychev I, Ritchie CW, Markus HS, O’Brien JT. 'Modifiable and non-modifiable risk factors of dementia and midlife cerebral small vessel disease in cognitively healthy midlife adults: the PREVENT-Dementia study.' Alz Res Therapy. 2022; 14:154.