Sally Hunter has spent more than two decades contributing to dementia research at the University of Cambridge, working with the Cambridge City over‑75s Cohort study (CC75C). During this time, she has been a strong critic of the relevance of the amyloid cascade hypothesis to the dementia syndrome in the older population. She proposed the Amyloid Precursor Protein (APP) Matrix Approach (AMA) to better model the behaviour of the amyloid beta protein in the context of its complex proteolytic system.
Her current work focuses on safeguarding and extending the scientific value of the CC75C legacy datasets and biological resources, which span over forty years of population-based research. Sally has played a key role in ensuring that these unique materials remain accessible for future research. Together with colleagues, she has been involved in establishing the new CC75C Research Data Access Portal, currently in development, which will provide a structured and sustainable route for researchers to engage with the cohort’s data and neuropathological resources.
Alongside her scientific work, Sally is also an artist whose practice explores the intersection of science and visual storytelling. Her artwork illustrates scientific concepts from research methods to the broader meanings behind data with the aim of engaging, entertaining, and enlightening diverse audiences. She has presented this work at the Cambridge Dementia Research Day on 28 April 2026, held at Magdalene College, Cripps Court Conference Centre. A selection of her work is available to view https://www.sallyhunter.co.uk/.
